Effect of in vivo hypoxic preconditioning on changes in intracellular calcium content induced by long-term anoxia in rat brain slices

被引：7
|
作者：
Semenov, DG [1 ]
Miller, OL [1 ]
Samoilov, MO [1 ]
机构：
[1] Russian Acad Sci, IP Pavlov Physiol Inst, St Petersburg 196140, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2004年 / 138卷 / 04期
关键词：
hypobaric hypoxia; preconditioning; calcium; brain slices;
D O I：
10.1007/s10517-005-0093-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied changes in intracellular calcium content induced by 10-min anoxia in olfactory cortex slices from rats exposed to single or 3-fold moderate hypobaric hypoxia ("ascend" at 5000 in). Repeated preconditioning with moderate hypobaric hypoxia produced a neuroprotective effect. This treatment abolished pathological calcium overload in brain slices induced in vitro by 10-min test anoxia.
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页码：338 / 340
页数：3
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