In this prospective study, we analyzed 30 male infants with increased neonatal 17-hydroxyprogesterone (17OH-P) (patients) and for comparison 52 age-matched healthy babies (control subjects) with the aim of investigating the hypothalamic-pituitary-testis axis in the first 6 months of life. Although T, FSH, and LH levels were not significantly different in patients and control subjects, inhibin B was higher in patients than in control subjects. Therefore we suggest a clinical follow-up of these babies during childhood and puberty to verify the evolution of their condition. (Fertil Steril (R) 2010;94:2350-2. (C) 2010 by American Society for Reproductive Medicine.)
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Obstetrix Med Grp, Ctr Res Educ & Qual, Campbell, CA 95008 USAObstetrix Med Grp, Ctr Res Educ & Qual, Campbell, CA 95008 USA
Combs, C. Andrew
Maurel, Kimberly
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Mednax Inc, Obstetrix Med Grp, Ctr Res Educ & Qual, Sunrise, FL USAObstetrix Med Grp, Ctr Res Educ & Qual, Campbell, CA 95008 USA
Maurel, Kimberly
Garite, Thomas J.
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Mednax Inc, Obstetrix Med Grp, Ctr Res Educ & Qual, Sunrise, FL USA
Univ Calif Irvine, Med Ctr, Irvine, CA USAObstetrix Med Grp, Ctr Res Educ & Qual, Campbell, CA 95008 USA