Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid

被引：18
|
作者：
Mariano Nascimento, Marcus Vinicius [1 ]
Galdino, Pablinny Moreira [1 ]
Florentino, Iziara Ferreira [1 ]
Sampaio, Bruno Leite [3 ]
Vanderlinde, Frederico Argollo [2 ]
de Paula, Jose Realino [3 ]
Costa, Elson Alves [1 ]
机构：
[1] Univ Fed Goias, Inst Ciencias Biol 2, Lab Farmacol Prod Nat, BR-74001970 Goiania, Go, Brazil
[2] Univ Fed Rural Rio de Janeiro, Dept Ciencias Fisiol, Seropedica, RJ, Brazil
[3] Univ Fed Goias, Fac Farm, Lab Pesquisa Prod Nat, BR-74001970 Goiania, Go, Brazil
来源：
JOURNAL OF NATURAL MEDICINES | 2011年 / 65卷 / 3-4期
关键词：
Medicinal plants; Analgesic activity; Bioactivity-guided fractionation; Neurogenic pain; Formalin test; FORMALIN TEST; ACETIC-ACID; NOCICEPTIVE RESPONSE; EXTRACT; PAIN; MICE; INVOLVEMENT; ANALGESICS; ANTAGONISM; EXPRESSION;
D O I：
10.1007/s11418-011-0517-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This study was performed to determine the antinociceptive and anti-inflammatory activities of ethanolic extract of Lafoensia pacari A. St.-Hil. (PEtExt) stem bark and its fractions using various animal models such as acetic acid-induced abdominal writhing, formalin-induced pain and croton oil-induced ear edema tests. The PEtExt inhibited the acetic acid-induced abdominal writhing, reduced the pain reaction time on both phases of the formalin test and decreased the edema in a dose-dependent manner. Pre-treatment with naloxone did not reverse the antinociceptive effect. Only the ethyl acetate fraction showed antinociceptive and anti-inflammatory effects. Our results also showed that this extract contains compounds with analgesic action independent of anti-inflammatory activity.
引用
收藏
页码：448 / 454
页数：7
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