Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid

被引：18
|
作者：
Mariano Nascimento, Marcus Vinicius [1 ]
Galdino, Pablinny Moreira [1 ]
Florentino, Iziara Ferreira [1 ]
Sampaio, Bruno Leite [3 ]
Vanderlinde, Frederico Argollo [2 ]
de Paula, Jose Realino [3 ]
Costa, Elson Alves [1 ]
机构：
[1] Univ Fed Goias, Inst Ciencias Biol 2, Lab Farmacol Prod Nat, BR-74001970 Goiania, Go, Brazil
[2] Univ Fed Rural Rio de Janeiro, Dept Ciencias Fisiol, Seropedica, RJ, Brazil
[3] Univ Fed Goias, Fac Farm, Lab Pesquisa Prod Nat, BR-74001970 Goiania, Go, Brazil
来源：
JOURNAL OF NATURAL MEDICINES | 2011年 / 65卷 / 3-4期
关键词：
Medicinal plants; Analgesic activity; Bioactivity-guided fractionation; Neurogenic pain; Formalin test; FORMALIN TEST; ACETIC-ACID; NOCICEPTIVE RESPONSE; EXTRACT; PAIN; MICE; INVOLVEMENT; ANALGESICS; ANTAGONISM; EXPRESSION;
D O I：
10.1007/s11418-011-0517-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This study was performed to determine the antinociceptive and anti-inflammatory activities of ethanolic extract of Lafoensia pacari A. St.-Hil. (PEtExt) stem bark and its fractions using various animal models such as acetic acid-induced abdominal writhing, formalin-induced pain and croton oil-induced ear edema tests. The PEtExt inhibited the acetic acid-induced abdominal writhing, reduced the pain reaction time on both phases of the formalin test and decreased the edema in a dose-dependent manner. Pre-treatment with naloxone did not reverse the antinociceptive effect. Only the ethyl acetate fraction showed antinociceptive and anti-inflammatory effects. Our results also showed that this extract contains compounds with analgesic action independent of anti-inflammatory activity.
引用
收藏
页码：448 / 454
页数：7
相关论文
共 50 条
  • [31] Ellagic acid (EA), a tannin was isolated from Eucalyptus citriodora leaves and its anti-inflammatory activity
    Yu Qiujian
    Feng Zongcai
    Huang Liping
    He Jingwei
    Zhou Zhongliu
    Liu Fang
    MEDICINAL CHEMISTRY RESEARCH, 2021, 30 (12) : 2277 - 2288
  • [32] Ellagic acid (EA), a tannin was isolated from Eucalyptus citriodora leaves and its anti-inflammatory activity
    Yu Qiujian
    Feng Zongcai
    Huang Liping
    He Jingwei
    Zhou Zhongliu
    Liu Fang
    Medicinal Chemistry Research, 2021, 30 : 2277 - 2288
  • [33] Chemical composition, antioxidant, anti-inflammatory and antinociceptive activities of the ethanol extract of ripe fruits of Solanum lycocarpum St. Hil. (Solanaceae)
    Morais, Melissa Grazielle
    Saldanha, Aline Aparecida
    Costa Rodrigues, Joao Paulo
    Mendes, Iara Cotta
    Ferreira, Leticia Marcelle
    Amado, Paula Avelar
    Farias, Katyuce de Souza
    Santos Zanuncio, Vanessa Samudio
    da Silva, Denise Brentan
    Horta Pinto, Flavia Carmo
    Soares, Adriana Cristina
    Rodrigues dos Santos Lima, Luciana Alves
    JOURNAL OF ETHNOPHARMACOLOGY, 2020, 262
  • [34] Epigallocatechin gallate, myricetin and ellagic acid glycosides with anti-inflammatory activity from Memecylon edule leaves
    Nualkaew, S.
    Thongpraditchote, S.
    Wongkrajang, Y.
    Umehara, K.
    Noguchi, H.
    PLANTA MEDICA, 2012, 78 (11) : 1189 - 1189
  • [35] Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity
    Kassim, Mustafa
    Achoui, Mouna
    Mustafa, Mohd Rais
    Mohd, Mustafa Ali
    Yusoff, Kamaruddin Mohd
    NUTRITION RESEARCH, 2010, 30 (09) : 650 - 659
  • [36] Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity
    Salathia, Saniya
    Gigliobianco, Maria Rosa
    Casadidio, Cristina
    Di Martino, Piera
    Censi, Roberta
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (08)
  • [37] In-vivo antinociceptive, anti-inflammatory and antipyretic activity of pistagremic acid isolated from Pistacia integerrima
    Rauf, Abdur
    Uddin, Ghias
    Siddiqui, Bina S.
    Khan, Ajmal
    Khan, Haroon
    Arfan, Mohammad
    Muhammad, Naveed
    Wadood, Abdul
    PHYTOMEDICINE, 2014, 21 (12) : 1509 - 1515
  • [38] Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis
    Marin, Marta
    Maria Giner, Rosa
    Rios, Jose-Luis
    Carmen Recio, Maria
    JOURNAL OF ETHNOPHARMACOLOGY, 2013, 150 (03) : 925 - 934
  • [39] A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats
    Mansouri, Mohammad Taghi
    Hemmati, Ali Asghar
    Naghizadeh, Bahareh
    Mard, Seyyed Ali
    Rezaie, Anahita
    Ghorbanzadeh, Behnam
    INDIAN JOURNAL OF PHARMACOLOGY, 2015, 47 (03) : 292 - 298
  • [40] Antinociceptive and anti-inflammatory effect of Passiflora edulis leaves extract in acetic acid-induced and oedema in vivo
    Sandhiutami, Ni Made Dwi
    Desmiaty, Yesi
    Fahleni
    Fakhran, Mohammad Haidi
    PHARMACY EDUCATION, 2024, 24 (02): : 78 - 85
12345