Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry

被引：46

作者：

Cagide, F. ^{[1
]}

Silva, T. ^{[1
]}

Reis, J. ^{[1
]}

Gaspar, A. ^{[1
]}

Borges, F. ^{[1
]}

Gomes, L. R. ^{[2
]}

Low, J. N. ^{[3
]}

机构：

[1] Univ Porto, Fac Ciencias, CIQUP Dept Quim & Bioquim, P-4169007 Oporto, Portugal

[2] Univ Fernando Pessoa, Escola Super Saude UFP, REQUIMTE FP ENAS Fac Ciencias Saude, P-4200150 Oporto, Portugal

[3] Univ Aberdeen, Dept Chem, Old Aberdeen AB24 3UE, Scotland

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 14期

关键词：

AMIDE BOND FORMATION; HETEROCYCLES; CHROMONE; SCAFFOLD;

D O I：

10.1039/c4cc08798d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The discovery of potent and selective monoamine oxidase-B inhibitors for the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is still a challenging endeavor. Herein, we report the discovery of two new classes of potent and selective MAO-B inhibitors based on chromane-2,4-dione and chromone-3-carboxamide scaffolds.

引用

页码：2832 / 2835

页数：4

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