Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry

被引：46
|
作者：
Cagide, F. [1 ]
Silva, T. [1 ]
Reis, J. [1 ]
Gaspar, A. [1 ]
Borges, F. [1 ]
Gomes, L. R. [2 ]
Low, J. N. [3 ]
机构：
[1] Univ Porto, Fac Ciencias, CIQUP Dept Quim & Bioquim, P-4169007 Oporto, Portugal
[2] Univ Fernando Pessoa, Escola Super Saude UFP, REQUIMTE FP ENAS Fac Ciencias Saude, P-4200150 Oporto, Portugal
[3] Univ Aberdeen, Dept Chem, Old Aberdeen AB24 3UE, Scotland
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 14期
关键词：
AMIDE BOND FORMATION; HETEROCYCLES; CHROMONE; SCAFFOLD;
D O I：
10.1039/c4cc08798d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The discovery of potent and selective monoamine oxidase-B inhibitors for the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is still a challenging endeavor. Herein, we report the discovery of two new classes of potent and selective MAO-B inhibitors based on chromane-2,4-dione and chromone-3-carboxamide scaffolds.
引用
收藏
页码：2832 / 2835
页数：4
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