Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry

被引：46

作者：

Cagide, F. ^{[1
]}

Silva, T. ^{[1
]}

Reis, J. ^{[1
]}

Gaspar, A. ^{[1
]}

Borges, F. ^{[1
]}

Gomes, L. R. ^{[2
]}

Low, J. N. ^{[3
]}

机构：

[1] Univ Porto, Fac Ciencias, CIQUP Dept Quim & Bioquim, P-4169007 Oporto, Portugal

[2] Univ Fernando Pessoa, Escola Super Saude UFP, REQUIMTE FP ENAS Fac Ciencias Saude, P-4200150 Oporto, Portugal

[3] Univ Aberdeen, Dept Chem, Old Aberdeen AB24 3UE, Scotland

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 14期

关键词：

AMIDE BOND FORMATION; HETEROCYCLES; CHROMONE; SCAFFOLD;

D O I：

10.1039/c4cc08798d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The discovery of potent and selective monoamine oxidase-B inhibitors for the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is still a challenging endeavor. Herein, we report the discovery of two new classes of potent and selective MAO-B inhibitors based on chromane-2,4-dione and chromone-3-carboxamide scaffolds.

引用

页码：2832 / 2835

页数：4

共 50 条

[1] ALIPHATIC PROPARGYLAMINES - POTENT, SELECTIVE, IRREVERSIBLE MONOAMINE OXIDASE-B INHIBITORS
YU, PH
DAVIS, BA
BOULTON, AA
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (20) : 3705 - 3713
[2] SELECTIVE INHIBITORS OF MONOAMINE OXIDASE-A AND OXIDASE-B
WILLIAMS, CH
BIOCHEMICAL PHARMACOLOGY, 1984, 33 (02) : 334 - 337
[3] Design of enamides as new selective monoamine oxidase-B inhibitors
Kavully, Fathima Sahla
Oh, Jong Min
Dev, Sanal
Kaipakasseri, Swafvan
Palakkathondi, Ashique
Vengamthodi, Ajeesh
Azeez, Rinshana Fathima Abdul
Tondo, Anna Rita
Nicolotti, Orazio
Kim, Hoon
Mathew, Bijo
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2020, 72 (07) : 916 - 926
[4] Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors
Hammuda, Arwa
Shalaby, Raed
Rovida, Stefano
Edmondson, Dale E.
Binda, Claudia
Khalil, Ashraf
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 114 : 162 - 169
[5] VINBLASTINE AND VINCRISTINE ARE INHIBITORS OF MONOAMINE OXIDASE-B
SON, JK
ROSAZZA, JPN
DUFFEL, MW
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (07) : 1845 - 1848
[6] NEW DIRECTIONS IN MONOAMINE OXIDASE-A AND OXIDASE-B - SELECTIVE INHIBITORS AND SUBSTRATES
YOUDIM, MBH
FINBERG, JPM
BIOCHEMICAL PHARMACOLOGY, 1991, 41 (02) : 155 - 162
[7] Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors
Oh, Jong Min
Rangarajan, T. M.
Chaudhary, Reeta
Singh, Rishi Pal
Singh, Manjula
Singh, Raj Pal
Tondo, Anna Rita
Gambacorta, Nicola
Nicolotti, Orazio
Mathew, Bijo
Kim, Hoon
MOLECULES, 2020, 25 (10):
[8] Monoamine oxidase-B inhibitors in the treatment of Alzheimers disease
Thomas, T
NEUROBIOLOGY OF AGING, 2000, 21 (02) : 343 - 348
[9] Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement?
Guglielmi, Paolo
Carradori, Simone
Ammazzalorso, Alessandra
Secci, Daniela
EXPERT OPINION ON DRUG DISCOVERY, 2019, 14 (10) : 995 - 1035
[10] A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors
Chimenti, Franco
Fioravanti, Rossella
Bolasco, Adriana
Chimenti, Paola
Secci, Daniela
Rossi, Francesca
Yanez, Matilde
Orallo, Francisco
Ortuso, Francesco
Alcaro, Stefano
Cirilli, Roberto
Ferretti, Rosella
Sanna, M. Luisa
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (03) : 1273 - 1279

← 1 2 3 4 5 →