Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats

被引：1
|
作者：
Farshid, Amir Abbas [1 ]
Tamaddonfard, Esmaeal [2 ]
Yahyaee, Fatere [1 ]
机构：
[1] Urmia Univ, Fac Vet Med, Div Pathol, Dept Pathobiol, Orumiyeh 57153, Iran
[2] Urmia Univ, Fac Vet Med, Div Physiol, Dept Basic Sci, Orumiyeh 57153, Iran
来源：
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY | 2010年 / 48卷 / 11期
关键词：
Carrageenan; Histidine; N acetylcysteine; Neutrophil infiltration; Paw edema; INDUCED HINDPAW EDEMA; INDUCED PAW EDEMA; NITRIC-OXIDE; HYDROGEN-SULFIDE; AMINO-ACIDS; BRAIN EDEMA; CARRAGEENAN; FORMALIN; HYPERALGESIA; HISTAMINE;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The intra-plantar injection of carrageenan elicited an Inflammatory response characterized by increase of the paw thickness and infiltration of neutrophils in paw tissues Histidine n acetylcysteine and diclofenac decreased paw thickness and neutrophil infiltration in the paw tissues The anti inflammatory effect induced by co administration of histidine and n acetylcysteine with diclofenac was more than that obtained from histidine and n-acetylcysteine administered alone The results suggested that histidine n acetylcysteine and diclofenac produced anti inflammatory activities by reducing paw edema and neutrophil infiltrationin induced by carrageenan Inhibition of cyclooxygenase products such as prostaglandins may be Involved in the anti-inflammatory effects induced by histidine and n-acetylcysteine
引用
收藏
页码：1136 / 1142
页数：7
相关论文
共 50 条
  • [31] Effects of N-acetylcysteine on the inflammatory response and bacterial translocation in a model of intestinal obstruction and ischemia in rats
    Costa, Rafael Izar Domingues da
    Fischer, Joao Marcos da Silva
    Rasslan, Roberto
    Koike, Marcia Kiyomi
    Utiyama, Edvaldo Massazo
    Montero, Edna Frasson de Souza
    ACTA CIRURGICA BRASILEIRA, 2022, 37 (12)
  • [32] Anti-Inflammatory and Analgesic Effects of Curcumin Nanoparticles Associated with Diclofenac Sodium in Experimental Acute Inflammation
    Boarescu, Ioana
    Pop, Raluca Maria
    Boarescu, Paul-Mihai
    Bocsan, Ioana Corina
    Gheban, Dan
    Rajnoveanu, Ruxandra-Mioara
    Rajnoveanu, Armand
    Bulboaca, Adriana Elena
    Buzoianu, Anca Dana
    Bolboaca, Sorana D.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (19)
  • [33] N-acetylcysteine expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic acid-induced colitis in rats
    Uraz, Suleyman
    Tahan, Gulgun
    Aytekin, Huseyin
    Tahan, Veysel
    SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2013, 73 (01): : 61 - 66
  • [34] N-Acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms
    Chantal Bémeur
    Javier Vaquero
    Paul Desjardins
    Roger F. Butterworth
    Metabolic Brain Disease, 2010, 25 : 241 - 249
  • [35] N-Acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms
    Bemeur, Chantal
    Vaquero, Javier
    Desjardins, Paul
    Butterworth, Roger F.
    METABOLIC BRAIN DISEASE, 2010, 25 (02) : 241 - 249
  • [36] Anti-Inflammatory Effect of Diclofenac Diethylammonium Gel on Acute Phase of Ligature Induced Periodontitis in Rats
    Botelho, Marco A.
    Paixao, Monica S.
    Rachid, Italo
    Bannet, Leonard Edward
    Patrus, Ana Helena
    Mattos, Thiago Borges
    Queiroz, Dinalva
    Ruela, Ronaldo
    Costa, Jose M. C.
    Quintans, Lucindo, Jr.
    LATIN AMERICAN JOURNAL OF PHARMACY, 2010, 29 (08): : 1371 - 1376
  • [37] Gallic Acid Exerts Nephroprotective, Anti-Oxidative Stress, and Anti-Inflammatory Effects Against Diclofenac-Induced Renal Injury in Malerats
    Moradi, Alireza
    Abolfathi, Mahdieh
    Javadian, Mahsa
    Heidarian, Esfandiar
    Roshanmehr, Hoshang
    Khaledi, Mansoor
    Nouri, Ali
    ARCHIVES OF MEDICAL RESEARCH, 2021, 52 (04) : 380 - 388
  • [38] Effects of N-acetylcysteine on myoglobinuric-acute renal failure in rats
    Fernández-Fúnez, A
    Polo, FJ
    Broseta, L
    Valer, J
    Zafrilla, L
    RENAL FAILURE, 2002, 24 (06) : 725 - 733
  • [39] The effects of L-carnitine and N-acetylcysteine on carbontetrachloride induced acute liver damage in rats
    Cetinkaya, A.
    Kantarceken, B.
    Bulbuloglu, E.
    Kurutas, E. B.
    Ciralik, H.
    Atli, Y.
    BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 2013, 114 (12): : 682 - 688
  • [40] N-Acetylcysteine enhances the action of anti-inflammatory drugs as suppressors of prostaglandin production in monocytes
    Hoffer, E
    Baum, Y
    Nahir, AM
    MEDIATORS OF INFLAMMATION, 2002, 11 (05) : 321 - 323
12345