Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats

被引：1

作者：

Farshid, Amir Abbas ^{[1
]}

Tamaddonfard, Esmaeal ^{[2
]}

Yahyaee, Fatere ^{[1
]}

机构：

[1] Urmia Univ, Fac Vet Med, Div Pathol, Dept Pathobiol, Orumiyeh 57153, Iran

[2] Urmia Univ, Fac Vet Med, Div Physiol, Dept Basic Sci, Orumiyeh 57153, Iran

来源：

INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY | 2010年 / 48卷 / 11期

关键词：

Carrageenan; Histidine; N acetylcysteine; Neutrophil infiltration; Paw edema; INDUCED HINDPAW EDEMA; INDUCED PAW EDEMA; NITRIC-OXIDE; HYDROGEN-SULFIDE; AMINO-ACIDS; BRAIN EDEMA; CARRAGEENAN; FORMALIN; HYPERALGESIA; HISTAMINE;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The intra-plantar injection of carrageenan elicited an Inflammatory response characterized by increase of the paw thickness and infiltration of neutrophils in paw tissues Histidine n acetylcysteine and diclofenac decreased paw thickness and neutrophil infiltration in the paw tissues The anti inflammatory effect induced by co administration of histidine and n acetylcysteine with diclofenac was more than that obtained from histidine and n-acetylcysteine administered alone The results suggested that histidine n acetylcysteine and diclofenac produced anti inflammatory activities by reducing paw edema and neutrophil infiltrationin induced by carrageenan Inhibition of cyclooxygenase products such as prostaglandins may be Involved in the anti-inflammatory effects induced by histidine and n-acetylcysteine

引用

页码：1136 / 1142

页数：7

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