Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats

被引：1
|
作者：
Farshid, Amir Abbas [1 ]
Tamaddonfard, Esmaeal [2 ]
Yahyaee, Fatere [1 ]
机构：
[1] Urmia Univ, Fac Vet Med, Div Pathol, Dept Pathobiol, Orumiyeh 57153, Iran
[2] Urmia Univ, Fac Vet Med, Div Physiol, Dept Basic Sci, Orumiyeh 57153, Iran
来源：
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY | 2010年 / 48卷 / 11期
关键词：
Carrageenan; Histidine; N acetylcysteine; Neutrophil infiltration; Paw edema; INDUCED HINDPAW EDEMA; INDUCED PAW EDEMA; NITRIC-OXIDE; HYDROGEN-SULFIDE; AMINO-ACIDS; BRAIN EDEMA; CARRAGEENAN; FORMALIN; HYPERALGESIA; HISTAMINE;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The intra-plantar injection of carrageenan elicited an Inflammatory response characterized by increase of the paw thickness and infiltration of neutrophils in paw tissues Histidine n acetylcysteine and diclofenac decreased paw thickness and neutrophil infiltration in the paw tissues The anti inflammatory effect induced by co administration of histidine and n acetylcysteine with diclofenac was more than that obtained from histidine and n-acetylcysteine administered alone The results suggested that histidine n acetylcysteine and diclofenac produced anti inflammatory activities by reducing paw edema and neutrophil infiltrationin induced by carrageenan Inhibition of cyclooxygenase products such as prostaglandins may be Involved in the anti-inflammatory effects induced by histidine and n-acetylcysteine
引用
收藏
页码：1136 / 1142
页数：7
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