Isolation and Anti-Inflammatory Activity Evaluation of Triterpenoids and a Monoterpenoid Glycoside from Harpagophytum procumbens

被引：14

作者：

Qi, Jin ^{[1
,2
]}

Li, Na ^{[2
]}

Zhou, Jia-Hong ^{[3
]}

Yu, Bo-Yang ^{[1
,2
]}

Qiu, Samuel X. ^{[4
]}

机构：

[1] China Pharmaceut Univ, Key Lab Modern TCM, Dept Pharmacognosy, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Dept Complex Prescript TCM, Nanjing 210009, Peoples R China

[3] Nanjing Normal Univ, Anal & Testing Ctr, Nanjing, Peoples R China

[4] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

PLANTA MEDICA | 2010年 / 76卷 / 16期

关键词：

Pedaliaceae; Harpagophytum procumbens (Burch.) DC ex Meissner subsp procumbens; devil's claw; terpenoids; monoterpenoid glycoside; neutrophil respiratory burst; DEVILS CLAW; PHENOLIC GLYCOSIDES; PRUNELLA-VULGARIS; CONSTITUENTS; LEAVES; BURST; ACID; DC;

D O I：

10.1055/s-0030-1250029

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new triterpenoid glycoside, designated harproside (1), and a new iridoid glycoside, named pagide (2), along with six known triterpenoids (3-8), were obtained from the tubers of Harpagophytum procumbens D.C. (devil's claw), and their structures were established through chemical methods and spectroscopic analyses. In an in vitro assay, the six triterpenoids showed anti-inflammatory activity. Compounds 3, 7, and 8 showed significant inhibitory activity against neutrophil respiratory burst stimulated by PMA, while compounds 4, 5, and 6 showed marginal inhibitory activity.

引用

页码：1892 / 1896

页数：5

共 50 条

[31] The discovery of an anti-inflammatory monoterpenoid, neoroseoside from the Zea mays
Tan, Hui
Lee, Hyun-jin
Hillman, Prima F.
Lee, Eun-Young
Lee, Chaeyoung
Seo, Eun Kyoung
Lee, Mi Ja
Nam, Sang-Jip
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 105
[32] Alteration of anti-inflammatory activity of Harpagophytum procumbens (devil's claw) extract after external metabolic activation with S9 mix
Hostanska, Katarina
Melzer, Joerg
Rostock, Matthias
Suter, Andy
Saller, Reinhard
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2014, 66 (11) : 1606 - 1614
[33] Isolation of dihydroagarofuran sesquiterpene from the fruits of Tripterygium hypoglaucum and evaluation of their anti-inflammatory activity
Wu, Shi-Li
Yang, Xing
Ning, Wen-Xiu
Wu, Gang-Yun
Dai, Xin-Yu
Zhang, Yu
Chen, Duo-Zhi
Ding, Xiao
He, Hong-Ping
Zhou, Wei
Hao, Xiao-Jiang
PHYTOCHEMISTRY, 2025, 236
[34] Conjugates of Lupane Triterpenoids with Arylpyrimidines: Synthesis and Anti-inflammatory Activity
Semenova, Maria D.
Popov, Sergey A.
Sorokina, Irina V.
Meshkova, Yulia V.
Baev, Dmitry S.
Tolstikova, Tatyana G.
Shults, Elvira E.
STEROIDS, 2022, 184
[35] Cytotoxic and Anti-inflammatory Triterpenoids from Toona ciliata
Zhang, Feng
Wang, Jun-Song
Gu, Yu-Cheng
Kong, Ling-Yi
JOURNAL OF NATURAL PRODUCTS, 2012, 75 (04): : 538 - 546
[36] Anti-Inflammatory Triterpenoids from the Stems of Microtropis Fokienensis
Chen, I-Hsiao
Du, Ying-Chi
Hwang, Tsong-Long
Chen, I-Fen
Lan, Yu-Hsuan
Yen, Hsin-Fu
Chang, Fang-Rong
Wu, Yang-Chang
MOLECULES, 2014, 19 (04): : 4608 - 4623
[37] Triterpenoids from Euphorbia maculata and Their Anti-Inflammatory Effects
Sun, Yi
Gao, Liang-liang
Tang, Meng-yue
Feng, Bao-min
Pei, Yue-hu
Yasukawa, Ken
MOLECULES, 2018, 23 (09):
[38] ANTI-INFLAMMATORY ACTIVITY OF NATURAL PRODUCTS .I. TRITERPENOIDS
GUPTA, MB
BHALLA, TN
GUPTA, GP
MITRA, CR
BHARGAVA, KP
EUROPEAN JOURNAL OF PHARMACOLOGY, 1969, 6 (01) : 67 - +
[39] Cytotoxic and anti-inflammatory polyacetylenes from Tridax procumbens L
Tan, Zhiqiao
Chen, Cong
Chen, Lu
Zeng, Jia
Zhang, Wenxin
Xu, Jingwen
He, Xiangjiu
Wang, Yihai
PHYTOCHEMISTRY, 2024, 225
[40] Anti-inflammatory triterpenoids from Alchornea cordifolia leaves
Osadebe, P. O.
Ebi, G. C.
Okoye, F. B. C.
PLANTA MEDICA, 2007, 73 (09) : 831 - 831

← 1 2 3 4 5 →