Isolation and Anti-Inflammatory Activity Evaluation of Triterpenoids and a Monoterpenoid Glycoside from Harpagophytum procumbens

被引：14
|
作者：
Qi, Jin [1 ,2 ]
Li, Na [2 ]
Zhou, Jia-Hong [3 ]
Yu, Bo-Yang [1 ,2 ]
Qiu, Samuel X. [4 ]
机构：
[1] China Pharmaceut Univ, Key Lab Modern TCM, Dept Pharmacognosy, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Dept Complex Prescript TCM, Nanjing 210009, Peoples R China
[3] Nanjing Normal Univ, Anal & Testing Ctr, Nanjing, Peoples R China
[4] Washington Univ, Dept Chem, St Louis, MO 63130 USA
来源：
PLANTA MEDICA | 2010年 / 76卷 / 16期
关键词：
Pedaliaceae; Harpagophytum procumbens (Burch.) DC ex Meissner subsp procumbens; devil's claw; terpenoids; monoterpenoid glycoside; neutrophil respiratory burst; DEVILS CLAW; PHENOLIC GLYCOSIDES; PRUNELLA-VULGARIS; CONSTITUENTS; LEAVES; BURST; ACID; DC;
D O I：
10.1055/s-0030-1250029
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new triterpenoid glycoside, designated harproside (1), and a new iridoid glycoside, named pagide (2), along with six known triterpenoids (3-8), were obtained from the tubers of Harpagophytum procumbens D.C. (devil's claw), and their structures were established through chemical methods and spectroscopic analyses. In an in vitro assay, the six triterpenoids showed anti-inflammatory activity. Compounds 3, 7, and 8 showed significant inhibitory activity against neutrophil respiratory burst stimulated by PMA, while compounds 4, 5, and 6 showed marginal inhibitory activity.
引用
收藏
页码：1892 / 1896
页数：5
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