[Ag(PcL)]-Catalyzed Domino Reactions of 2-Alkynylbenzaldehydes with Electron-Poor Anilines: Synthesis of 1-Aminoisochromenes

被引：10
|
作者：
Pirovano, Valentina [1 ]
Hamdan, Gabriele [1 ]
Garanzini, Davide [1 ]
Brambilla, Elisa [1 ]
Rossi, Elisabetta [1 ]
Caselli, Alessandro [2 ,3 ]
Abbiati, Giorgio [1 ]
机构：
[1] Univ Milan, Sez Chim Gen & Organ A Marchesini, Dipartimento Sci Farmaceut, Via Venezian 21, I-20133 Milan, Italy
[2] Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy
[3] CNR, SCITEC, Via Golgi 19, I-20133 Milan, Italy
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 17期
关键词：
Isochromenes; Alkynes; Domino reactions; Silver; Electron-poor anilines; Macrocyclic ligands; CYCLIC ALKENYL ETHERS; O-ALKYNYLBENZALDEHYDES; LEWIS-ACID; CYCLIZATION; HETEROCYCLES; ALKYNES; SILVER; ISOQUINOLINES; DERIVATIVES; CATALYST;
D O I：
10.1002/ejoc.202000275
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this paper, we describe the synthesis of neglected 1-aminoisochromene derivatives starting from 2-alkynylbenzaldehydes and electron-poor anilines. The domino reaction is catalyzed by original [(AgPcL)-Pc-I] complexes and occurs with complete regioselectivity under mild conditions. The approach well-tolerates different aryl, heteroaryl, alkyl and cycloalkyl substituents on alkyne terminus to give the desired products in modest to very good yields.
引用
收藏
页码：2592 / 2599
页数：8
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