HIV-1 Latency Is Maintained by the Estrogen Receptor

被引：1

作者：

Bick, Alexis J. ^{[1
]}

Hapgood, Janet P. ^{[1
,2
]}

机构：

[1] Univ Cape Town, Dept Mol & Cell Biol, Cape Town, South Africa

[2] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa

来源：

TRENDS IN MICROBIOLOGY | 2018年 / 26卷 / 11期

关键词：

TRANSCRIPTION;

D O I：

10.1016/j.tim.2018.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Persistence of the latent reservoir remains a challenge to curing HIV infection. Using shRNA screening, new insights into the molecular mechanisms underlying latency regulation indicate that the estrogen receptor is a potent repressor of proviral reactivation and may serve as a promising therapeutic target in combination with other latency-reversing agents.

引用

页码：891 / 892

页数：2

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