HIV-1 Latency Is Maintained by the Estrogen Receptor

被引：1

作者：

Bick, Alexis J. ^{[1
]}

Hapgood, Janet P. ^{[1
,2
]}

机构：

[1] Univ Cape Town, Dept Mol & Cell Biol, Cape Town, South Africa

[2] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa

来源：

TRENDS IN MICROBIOLOGY | 2018年 / 26卷 / 11期

关键词：

TRANSCRIPTION;

D O I：

10.1016/j.tim.2018.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Persistence of the latent reservoir remains a challenge to curing HIV infection. Using shRNA screening, new insights into the molecular mechanisms underlying latency regulation indicate that the estrogen receptor is a potent repressor of proviral reactivation and may serve as a promising therapeutic target in combination with other latency-reversing agents.

引用

页码：891 / 892

页数：2

共 50 条

[21] HIV-1 Latency and Latency Reversal: Does Subtype Matter?
Sarabia, Indra
Bosque, Alberto
VIRUSES-BASEL, 2019, 11 (12):
[22] Epigenetic Heterogeneity in HIV-1 Latency Establishment
Matsuda, Yuka
Kobayashi-Ishihara, Mie
Fujikawa, Dai
Ishida, Takaomi
Watanabe, Toshiki
Yamagishi, Makoto
SCIENTIFIC REPORTS, 2015, 5
[23] No change to HIV-1 latency with valproate therapy
Steel, Alan
Clark, Sally
Teo, Ian
Shaunak, Sunil
Nelson, Mark
Gazzard, Brian
Kelleher, Peter
AIDS, 2006, 20 (12) : 1681 - 1682
[24] Experimental approaches to the study of HIV-1 latency
Han, Yefei
Wind-Rotolo, Megan
Yang, Hung-Chih
Siliciano, Janet D.
Siliciano, Robert F.
NATURE REVIEWS MICROBIOLOGY, 2007, 5 (02) : 95 - 106
[25] Keeping quiet: microRNAs in HIV-1 latency
Han, Yefei
Siliciano, Robert F.
NATURE MEDICINE, 2007, 13 (10) : 1138 - 1140
[26] Epigenetic Regulation of HIV-1 Latency in Astrocytes
Narasipura, Srinivas D.
Kim, Stephanie
Al-Harthi, Lena
JOURNAL OF VIROLOGY, 2014, 88 (05) : 3031 - 3038
[27] Epigenetic Heterogeneity in HIV-1 Latency Establishment
Yuka Matsuda
Mie Kobayashi-Ishihara
Dai Fujikawa
Takaomi Ishida
Toshiki Watanabe
Makoto Yamagishi
Scientific Reports, 5
[28] Reversal of Latency as Part of a Cure for HIV-1
Rasmussen, Thomas Aagaard
Tolstrup, Martin
Sogaard, Ole Schmeltz
TRENDS IN MICROBIOLOGY, 2016, 24 (02) : 90 - 97
[29] Therapeutics for HIV-1 reactivation from latency
Sgarbanti, Marco
Battistini, Angela
CURRENT OPINION IN VIROLOGY, 2013, 3 (04) : 394 - 401
[30] Animal models of HIV-1 latency and persistence
Brown, Helen J.
Zack, Jerome A.
CURRENT OPINION IN HIV AND AIDS, 2006, 1 (02) : 103 - 107

← 1 2 3 4 5 →