HIV-1 Latency Is Maintained by the Estrogen Receptor

被引：1

作者：

Bick, Alexis J. ^{[1
]}

Hapgood, Janet P. ^{[1
,2
]}

机构：

[1] Univ Cape Town, Dept Mol & Cell Biol, Cape Town, South Africa

[2] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa

来源：

TRENDS IN MICROBIOLOGY | 2018年 / 26卷 / 11期

关键词：

TRANSCRIPTION;

D O I：

10.1016/j.tim.2018.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Persistence of the latent reservoir remains a challenge to curing HIV infection. Using shRNA screening, new insights into the molecular mechanisms underlying latency regulation indicate that the estrogen receptor is a potent repressor of proviral reactivation and may serve as a promising therapeutic target in combination with other latency-reversing agents.

引用

页码：891 / 892

页数：2

共 50 条

[1] Molecular basis of HIV-1 latency Part I: physiology of HIV-1 latency
Schwartz, Christian
Le Douce, Valentin
Cherrier, Thomas
Redel, Laetitia
Marban, Wine
Aunis, Dominique
Rohr, Olivier
M S-MEDECINE SCIENCES, 2010, 26 (02): : 159 - 163
[2] Latency and reservoirs for HIV-1
Siliciano, RF
AIDS, 1999, 13 : S49 - S58
[3] HIV-1 Latency by Transition
Julg, Boris
Barouch, Dan H.
IMMUNITY, 2017, 47 (04) : 611 - 612
[4] Viral latency of HIV-1
Bouchat, Sophie
Van Lint, Carine
VIROLOGIE, 2019, 23 (04) : 195 - 210
[5] HIV-1 Latency Preface
Silvestri, Guido
Lichterfeld, Mathias
HIV-1 LATENCY, 2018, 417 : V - VI
[6] MECHANISMS OF HIV-1 LATENCY
BEDNARIK, DP
FOLKS, TM
AIDS, 1992, 6 (01) : 3 - 16
[7] Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir
Das, Biswajit
Dobrowolski, Curtis
Luttge, Benjamin
Valadkhan, Saba
Chomont, Nicolas
Johnston, Rowena
Bacchetti, Peter
Hoh, Rebecca
Gandhi, Monica
Deeks, Steven G.
Scully, Eileen
Karn, Jonathan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (33) : E7795 - E7804
[8] Molecular Understanding of HIV-1 Latency
Abbas, W.
Herbein, G.
ADVANCES IN VIROLOGY, 2012, 2012
[9] An Integrated Overview of HIV-1 Latency
Ruelas, Debbie S.
Greene, Warner C.
CELL, 2013, 155 (03) : 519 - 529
[10] Latency: the hidden HIV-1 challenge
Marcello, Alessandro
RETROVIROLOGY, 2006, 3 (1)

← 1 2 3 4 5 →