Preparation of tetrasubstituted pyrimido[4,5-d]pyrimidine diones

被引：13

作者：

Wang, Hui ^{[1
]}

Wang, Chao ^{[1
]}

Bannister, Thomas D. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 15期

关键词：

Pyrimidopyrimidines; Synthesis; Heterocycles; Antitumor; Inhibitor; MONOCARBOXYLATE TRANSPORTER MCT1; DERIVATIVES; PYRIMIDINES; INHIBITORS; BLOCKERS; AGENTS;

D O I：

10.1016/j.tetlet.2015.02.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel synthetic route to 1,3,5,7-tetrasubstituted pyrimido[4,5-d]pyrimidine-2,4-diones, of interest for potential antitumor activity, is reported. The route uses 1,3-disubstituted 6-amino uracils as starting materials. The key step is a hydrazine-induced cyclization reaction to form the fused pyrimidine ring. By choosing different uracils, acylation reagents, and alkylation reagents, substituents at N-1, N-3, C-5, and C-7 may be selectively varied to provide a structurally diverse set of compounds for biological evaluation. (C) 2015 Published by Elsevier Ltd.

引用

页码：1949 / 1952

页数：4

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