Preparation of tetrasubstituted pyrimido[4,5-d]pyrimidine diones

被引：13
|
作者：
Wang, Hui [1 ]
Wang, Chao [1 ]
Bannister, Thomas D. [1 ]
机构：
[1] Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 15期
关键词：
Pyrimidopyrimidines; Synthesis; Heterocycles; Antitumor; Inhibitor; MONOCARBOXYLATE TRANSPORTER MCT1; DERIVATIVES; PYRIMIDINES; INHIBITORS; BLOCKERS; AGENTS;
D O I：
10.1016/j.tetlet.2015.02.051
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel synthetic route to 1,3,5,7-tetrasubstituted pyrimido[4,5-d]pyrimidine-2,4-diones, of interest for potential antitumor activity, is reported. The route uses 1,3-disubstituted 6-amino uracils as starting materials. The key step is a hydrazine-induced cyclization reaction to form the fused pyrimidine ring. By choosing different uracils, acylation reagents, and alkylation reagents, substituents at N-1, N-3, C-5, and C-7 may be selectively varied to provide a structurally diverse set of compounds for biological evaluation. (C) 2015 Published by Elsevier Ltd.
引用
收藏
页码：1949 / 1952
页数：4
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