Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1

被引：137
|
作者：
Fujii, Ken
Hurley, James H.
Freed, Eric O. [1 ]
机构：
[1] NCI, HIV Drug Resistance Program, Virus Cell Interact Sect, Frederick, MD 21702 USA
[2] NIH, Natl Inst Diabet & Digest & Kidney Dis, Mol Biol Lab, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 12期
关键词：
D O I：
10.1038/nrmicro1790
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The limited coding capacity of retroviral genomes forces these viruses to rely heavily on the host-cell machinery for their replication. This phenomenon is particularly well illustrated by the interaction between retroviruses and components of the endosomal budding machinery that occurs during virus release. Here, we focus on the use of host-cell factors during HIV-1 budding and highlight recent progress in our understanding of the role of one such factor, Alix, in both viral and cellular membrane budding and fission events.
引用
收藏
页码：912 / 916
页数：5
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