Determination of Salbutamol Sulfate Based on Chitosan Multi-Wall Carbon Nanotubes Film Modified Glassy Carbon Electrode

被引:11
|
作者
Cao, Zhong [1 ]
Zhao, Yu-Ting [1 ,2 ]
Dai, Yi-Min [1 ]
Long, Shu [1 ]
Guo, Xiao-Cui [1 ]
Yang, Rong-Hua [3 ]
机构
[1] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410004, Hunan, Peoples R China
[2] Ningxia Ctr Dis Prevent & Control, Yinchuan 750004, Peoples R China
[3] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
关键词
Salbutamol Sulfate; Chitosan; Multi-Walled Carbon Nanotubes; Carboxylated; Pharmaceutical Analysis; INJECTION SPECTROPHOTOMETRIC DETERMINATION; PERFORMANCE LIQUID-CHROMATOGRAPHY; PHARMACEUTICAL FORMULATIONS; VALIDATION; FENOTEROL; SENSORS; ASSAY;
D O I
10.1166/sl.2011.1549
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
An electrochemical glassy carbon electrode (GCE) modified with a composite film of carboxylated multi-walled carbon nanotubes (MWNTs) and chitosan has been constructed in this paper. It shows excellent electro-catalytic activity toward the electrochemical oxidation of salbutamol sulfate in phosphate buffer. The oxidation peak currents of the electrode are linearly correlated to the concentration of salbutamol sulfate in the range of 0.50-40 mu mol/L with a detection limit of 0.086 mu mol/L. The electrode possesses a nice recovery of 96.71-106.4% with good reproducibility, stability, selectivity and long lifetime for salbutamol sulfate aerosol samples in comparison with spectrophotometric method, indicating that it is a feasible method for rapid determination of pharmaceutical samples containing salbutamol sulfate.
引用
收藏
页码:1985 / 1989
页数:5
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