Zn-proline catalyzed selective synthesis of 1,2-disubstituted benzimidazoles in water

被引:61
|
作者
Ravi, Varala [1 ]
Ramu, Enugala [1 ]
Vuay, Kotra [1 ]
Rao, Adapa Srinivas [1 ]
机构
[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India
关键词
benzimidazole; zinc proline; water; recyclability;
D O I
10.1248/cpb.55.1254
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Zn-proline (5 mol%) performs as a novel water-soluble and recyclable Lewis acid catalyst for the selective synthesis of 1,2-disubstituted benzimidazoles from wide range of substituted o-phenylenediamines and aldehydes in moderate to excellent isolated yields (42-92%) using water as solvent at ambient temperature.
引用
收藏
页码:1254 / 1257
页数:4
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