Zn-proline catalyzed selective synthesis of 1,2-disubstituted benzimidazoles in water

被引：61

作者：

Ravi, Varala ^{[1
]}

Ramu, Enugala ^{[1
]}

Vuay, Kotra ^{[1
]}

Rao, Adapa Srinivas ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 08期

关键词：

benzimidazole; zinc proline; water; recyclability;

D O I：

10.1248/cpb.55.1254

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Zn-proline (5 mol%) performs as a novel water-soluble and recyclable Lewis acid catalyst for the selective synthesis of 1,2-disubstituted benzimidazoles from wide range of substituted o-phenylenediamines and aldehydes in moderate to excellent isolated yields (42-92%) using water as solvent at ambient temperature.

引用

页码：1254 / 1257

页数：4

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