Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

被引：27
|
作者：
Lam, Sio-Hong [1 ]
Chen, Po-Hsun [2 ]
Hung, Hsin-Yi [1 ]
Hwang, Tsong-Long [3 ,4 ,5 ]
Chiang, Chih-Chao [6 ,7 ,8 ]
Tran Dinh Thang [9 ,10 ]
Kuo, Ping-Chung [1 ]
Wu, Tian-Shung [1 ,11 ]
机构：
[1] Natl Cheng Kung Univ, Sch Pharm, Coll Med, Tainan 701, Taiwan
[2] Natl Formosa Univ, Dept Biotechnol, Huwei Township 632, Yunlin, Taiwan
[3] Chang Gung Univ, Grad Inst Nat Prod, Sch Tradit Chinese Med, Coll Med, Taoyuan 333, Taiwan
[4] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Res Ctr Food & Cosmet Safety, Res Ctr Chinese Herbal Med,Coll Human Ecol, Taoyuan 333, Taiwan
[5] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 333, Taiwan
[6] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, Taoyuan 338, Taiwan
[7] Taoyuan Chinese Med Assoc, Supervisor Board, Taoyuan 338, Taiwan
[8] Dazhu Fengze Chinese Med Clin, Taoyuan 338, Taiwan
[9] Vinh Univ, Sch Chem Biol & Environm, Vinh City 44000, Vietnam
[10] Nguyen Tat Thanh Univ, NTT Inst High Technol, Ho Chi Minh City 700000, Vietnam
[11] Tajen Univ, Dept Pharm, Coll Pharm & Hlth Care, Pingtung 907, Taiwan
来源：
MOLECULES | 2018年 / 23卷 / 10期
关键词：
Menispermaceae; lignan; pyrrole alkaloid; superoxide anion generation; elastase release; INHIBITS SUPEROXIDE-PRODUCTION; PHENOLIC-COMPOUNDS; PYRROLE ALKALOIDS; HUMAN NEUTROPHILS; BARK; DERIVATIVES; GLYCOSIDES; ROOTS; ANTIOXIDANT; STEROLS;
D O I：
10.3390/molecules23102541
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.
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页数：12
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