Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

被引：27

作者：

Lam, Sio-Hong ^{[1
]}

Chen, Po-Hsun ^{[2
]}

Hung, Hsin-Yi ^{[1
]}

Hwang, Tsong-Long ^{[3
,4
,5
]}

Chiang, Chih-Chao ^{[6
,7
,8
]}

Tran Dinh Thang ^{[9
,10
]}

Kuo, Ping-Chung ^{[1
]}

Wu, Tian-Shung ^{[1
,11
]}

机构：

[1] Natl Cheng Kung Univ, Sch Pharm, Coll Med, Tainan 701, Taiwan

[2] Natl Formosa Univ, Dept Biotechnol, Huwei Township 632, Yunlin, Taiwan

[3] Chang Gung Univ, Grad Inst Nat Prod, Sch Tradit Chinese Med, Coll Med, Taoyuan 333, Taiwan

[4] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Res Ctr Food & Cosmet Safety, Res Ctr Chinese Herbal Med,Coll Human Ecol, Taoyuan 333, Taiwan

[5] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 333, Taiwan

[6] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, Taoyuan 338, Taiwan

[7] Taoyuan Chinese Med Assoc, Supervisor Board, Taoyuan 338, Taiwan

[8] Dazhu Fengze Chinese Med Clin, Taoyuan 338, Taiwan

[9] Vinh Univ, Sch Chem Biol & Environm, Vinh City 44000, Vietnam

[10] Nguyen Tat Thanh Univ, NTT Inst High Technol, Ho Chi Minh City 700000, Vietnam

[11] Tajen Univ, Dept Pharm, Coll Pharm & Hlth Care, Pingtung 907, Taiwan

来源：

MOLECULES | 2018年 / 23卷 / 10期

关键词：

Menispermaceae; lignan; pyrrole alkaloid; superoxide anion generation; elastase release; INHIBITS SUPEROXIDE-PRODUCTION; PHENOLIC-COMPOUNDS; PYRROLE ALKALOIDS; HUMAN NEUTROPHILS; BARK; DERIVATIVES; GLYCOSIDES; ROOTS; ANTIOXIDANT; STEROLS;

D O I：

10.3390/molecules23102541

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

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页数：12

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