Radical Alkylation of Imines with 4-Alkyl-1,4-dihydropyridines Enabled by Photoredox/Bronsted Acid Cocatalysis

被引：85
|
作者：
Zhang, Hong-Hao [1 ]
Yu, Shouyun [1 ]
机构：
[1] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Jiangsu Key Lab Adv Organ Mat, Sch Chem & Chem Engn, Nanjing 210023, Jiangsu, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 19期
基金：
中国国家自然科学基金;
关键词：
COUPLED ELECTRON-TRANSFER; CARBON-CARBON BOND; VISIBLE-LIGHT; HANTZSCH ESTER; TRANSFER HYDROGENATION; SYNTHETIC APPLICATIONS; ASYMMETRIC ALKYLATION; CATALYSIS; CHEMISTRY; ALDEHYDES;
D O I：
10.1021/acs.joc.7b01425
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Radical alkylation of imines with 4-alkyl-1,4-dihydropyridines cocatalyzed by iridium/ruthenium complex and Bronsted acid under visible light irradiation has been achieved. Both aldimines and ketithines can undergo this transformation. Common functional groups, such as hydroxyl groups, ester, amide, ether, cyanide, and heterocycles, can be tolerated in this reaction. A variety of structurally diverse amines (57 examples) have been produced with up to 98% isolated yields using this method.
引用
收藏
页码：9995 / 10006
页数：12
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