Photoredox Defluorinative Alkylation of 1-Trifluoromethyl Alkenes and 1,3-Butadienes with 1,4-Dihydropyridines as Alkylation Reagents

被引：53
|
作者：
Chen, Haoguo [1 ]
Anand, Devireddy [1 ]
Zhou, Lei [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem, 135 Xingang West Rd, Guangzhou 510275, Guangdong, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 05期
基金：
中国国家自然科学基金;
关键词：
alkylation; C-F bond cleavage; difluoroalkenes; photoredox; radicals; NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION; GEM-DIFLUOROALKENES; ADDITION-REACTION; RADICAL-ADDITION; ALPHA; FLUORINE; 4-ALKYL-1,4-DIHYDROPYRIDINES; FUNCTIONALIZATION; ELIMINATION; ESTERS;
D O I：
10.1002/ajoc.201900026
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A radical defluorinative alkylation method of 1-trifluoromethyl alkenes and 1,3-butadienes with 4-alkyl-1,4-dihydropyridines under visible light irradiation is presented. Various alkylated 1,1-difluoroalkenes and 1,1-difluorodienes were obtained in moderate to high yields through a sequential C-C and C-F bond cleavage process.
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页码：661 / 664
页数：4
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