Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma

被引：66
|
作者：
Tsai, JH
Hsieh, YS
Kuo, SJ
Chen, ST
Yu, SY
Huang, CY
Chang, AC
Wang, YW
Tsai, MT
Liu, JY [1 ]
机构：
[1] Chung Shan Med & Dent Coll, Inst Biochem, Taichung 402, Taiwan
[2] Fooyin Inst Technol, Dept Nursing, Kaohsiung 831, Taiwan
[3] Changhua Christian Hosp, Dept Surg, Changhua 500, Taiwan
来源：
CANCER LETTERS | 2000年 / 161卷 / 02期
关键词：
human hepatocellular carcinoma; protein kinase C isoforms; protein kinase C activity;
D O I：
10.1016/S0304-3835(00)00597-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study was designed to investigate the alterations of individual protein kinase C (PKC) isoforms in human liver cancer. Surgical specimens of hepatocellular carcinoma and adjacent normal tissues were extracted into cytosolic and membranous fractions. The level of membrane-bound PKC alpha in the cancer tissue was significantly lower than that in the adjacent normal tissue and consistent with the change in PKC activity. In addition, there was a significant negative correlation between PKC alpha and tumor size. In both cytosolic and membrane fractions, levels of PKC delta and PKC xi was significantly higher in the cancer tissue than those in the adjacent normal liver tissue. The alterations in the PKC isoforms signify their roles in the hyperproliferation in liver cancer. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：171 / 175
页数：5
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