Alteration in the expression of protein kinase C isoforms in human hepatocellular carcinoma

被引：66
|
作者：
Tsai, JH
Hsieh, YS
Kuo, SJ
Chen, ST
Yu, SY
Huang, CY
Chang, AC
Wang, YW
Tsai, MT
Liu, JY [1 ]
机构：
[1] Chung Shan Med & Dent Coll, Inst Biochem, Taichung 402, Taiwan
[2] Fooyin Inst Technol, Dept Nursing, Kaohsiung 831, Taiwan
[3] Changhua Christian Hosp, Dept Surg, Changhua 500, Taiwan
来源：
CANCER LETTERS | 2000年 / 161卷 / 02期
关键词：
human hepatocellular carcinoma; protein kinase C isoforms; protein kinase C activity;
D O I：
10.1016/S0304-3835(00)00597-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study was designed to investigate the alterations of individual protein kinase C (PKC) isoforms in human liver cancer. Surgical specimens of hepatocellular carcinoma and adjacent normal tissues were extracted into cytosolic and membranous fractions. The level of membrane-bound PKC alpha in the cancer tissue was significantly lower than that in the adjacent normal tissue and consistent with the change in PKC activity. In addition, there was a significant negative correlation between PKC alpha and tumor size. In both cytosolic and membrane fractions, levels of PKC delta and PKC xi was significantly higher in the cancer tissue than those in the adjacent normal liver tissue. The alterations in the PKC isoforms signify their roles in the hyperproliferation in liver cancer. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：171 / 175
页数：5
相关论文
共 50 条
  • [21] Expression and translocation of protein kinase C isoforms in human antral G cells.
    Moore, E
    Buchan, AMJ
    GASTROENTEROLOGY, 1998, 114 (04) : A1166 - A1166
  • [22] Expression of Variant Isoforms of the Tyrosine Kinase SYK Determines the Prognosis of Hepatocellular Carcinoma
    Hong, Jian
    Yuan, Yunfei
    Wang, Jianping
    Liao, Yadi
    Zou, Ruhai
    Zhu, Chuanlong
    Li, Binkui
    Liang, Yi
    Huang, Pinzhu
    Wang, Zongwei
    Lin, Wenyu
    Zeng, Yixin
    Dai, Jia Le
    Chung, Raymond T.
    CANCER RESEARCH, 2014, 74 (06) : 1845 - 1856
  • [23] Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms
    Franz, MG
    Norman, JG
    Fabri, PJ
    Gower, WR
    ANNALS OF SURGICAL ONCOLOGY, 1996, 3 (06) : 564 - 569
  • [24] Protein kinase C δ regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma
    Takai, Shinji
    Matsushima-Nishiwaki, Rie
    Tokuda, Haruhiko
    Yasuda, Eisuke
    Toyoda, Hidenori
    Kaneoka, Yuji
    Yamaguchi, Akihiro
    Kumada, Takashi
    Kozawa, Osamu
    LIFE SCIENCES, 2007, 81 (07) : 585 - 591
  • [25] ENHANCED EXPRESSION OF PROTEIN-KINASE-C ISOZYMES IN HEPATOCELLULAR-CARCINOMA TISSUES
    FUKUSATO, T
    MACHINAMI, R
    HEPATOLOGY, 1990, 12 (02) : 404 - 404
  • [26] Expression of protein kinase C isoforms in osteoblastic cells.
    Lampasso, J
    Loza, J
    Stephan, E
    Dziak, R
    JOURNAL OF DENTAL RESEARCH, 1996, 75 : 3117 - 3117
  • [27] The expression of protein kinase C isoforms in salivary cells.
    Zhang, GH
    Mörk, AC
    Sun, XH
    Martinez, JR
    FASEB JOURNAL, 1999, 13 (04): : A467 - A467
  • [28] EXPRESSION OF PROTEIN-KINASE-C ISOFORMS IN RENAL TISSUE
    OSTLUND, E
    MENDEZ, CF
    JACOBSSON, G
    FRYCKSTEDT, J
    MEISTER, B
    APERIA, A
    KIDNEY INTERNATIONAL, 1995, 47 (03) : 766 - 773
  • [29] Molecular Cloning and Expression of Starfish Protein Kinase C Isoforms
    Miyake, Yasuo
    Yasui, Masaru
    Ikeda, Kaori
    Kondo, Tsunenori
    Tsukamoto, Shinpei
    Hori, Chinami
    Okemoto, Naomi
    Mashou, Keiko
    Bando, Reiko
    Nakamura, Naoko
    Toraya, Tetsuo
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2009, 73 (07) : 1550 - 1560
  • [30] EXPRESSION OF HGF AND C-MET PROTEIN IN HUMAN HEPATOCELLULAR-CARCINOMA
    UEKI, T
    SUZUKI, T
    OKAMOTO, E
    YAMAMOTO, H
    NAKANISHI, K
    FUJIMOTO, J
    HEPATOLOGY, 1995, 22 (04) : 338 - 338
12345