Antileukemic Activity and Chemical Constituents of Some Zingiberaceae Species

被引：0

作者：

Sukari, M. A. ^{[1
]}

Tang, S. W. ^{[1
]}

Neoh, B. K. ^{[1
]}

Ee, G. C. L. ^{[1
]}

Rahmani, M. ^{[1
]}

机构：

[1] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor Darul, Malaysia

来源：

ASIAN JOURNAL OF CHEMISTRY | 2010年 / 22卷 / 10期

关键词：

Zingiberaceae; Antileukemic; Alpinia; Zingiber; Kaempferia; KAEMPFERIA-GALANGA; PRINCIPLES; RHIZOME;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Crude extracts of various solvents from six species (genus Alpinia, Zingiber, Kaempferia) of Zingiberaceae family have been chosen for the in vitro cytotoxic activity screening against the inhibition of HL-60 cell line (Human promyelocytic leukemia). Eight extracts (44%) were found to have cytotoxic activity with IC50 values less than 30 mu g/mL, with Alpinia galanga showing the most prominent antileukemic activity. Further isolation work on Kaempferia galanga has yielded ethyl p-methoxy-trans-cinnamate (1), p-methoxy-trans-cinnamic acid (2) besides beta-sitosterol.

引用

页码：7891 / 7896

页数：6

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