Targeting PI3K-AKT-mTOR Signaling in Multiple Myeloma Mesenchymal Stem Cells Mediates Antiproliferative Effect on Myeloma Cells

被引：0
|
作者：
Heinmann, Luca [1 ]
Noman, Helal Mohammed Mohammed Ahmed [1 ]
Moelers, Klara [1 ]
Nimmagadda, Subbaiah Chary [1 ]
Sun, Kaiyan [1 ]
Frank, Daria [1 ]
Korab, Hanna [2 ]
Wei, Lanying [3 ]
Baumann, Anja [2 ]
Poos, Alexandra [2 ]
Raab, Marc-Steffen [4 ,5 ]
Lenz, Georg [6 ]
Khandanpour, Cyrus [1 ]
机构：
[1] Univ Hosp Muenster, Dept Med A, Munster, Germany
[2] German Canc Res Ctr, Clin Cooperat Unit CCU Mol Hematol Oncol, Heidelberg, Germany
[3] Univ Hosp Muenster, Inst Med Informat, Munster, Germany
[4] Heidelberg Univ, German Canc Res Ctr DKFZ, Clin Cooperat Unit Mol Hematol Oncol, Heidelberg, Germany
[5] Heidelberg Univ, Dept Internal Med 5, Heidelberg, Germany
[6] Univ Hosp Muenster, Dept Med Hematol Oncol & Pneumol A, Munster, Germany
来源：
BLOOD | 2021年 / 138卷
关键词：
D O I：
10.1182/blood-2021-150413
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1600
引用
收藏
页数：3
相关论文
共 50 条
  • [31] The Regulation of Lipid Deposition by Insulin in Goose Liver Cells Is Mediated by the PI3K-AKT-mTOR Signaling Pathway
    Han, Chunchun
    Wei, Shouhai
    He, Fang
    Liu, Dandan
    Wan, Huofu
    Liu, Hehe
    Li, Liang
    Xu, Hongyong
    Du, Xiaohui
    Xu, Feng
    PLOS ONE, 2015, 10 (05):
  • [32] Sodium cantharidate promotes autophagy in breast cancer cells by inhibiting the PI3K-Akt-mTOR signaling pathway
    Pang, Jin-Long
    Xu, Lian-Song
    Zhao, Qian
    Niu, Wen-Wen
    Rong, Xiang-Yu
    Li, Shan-Shan
    Li, Xian
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [33] Inhibition of PI3K-AKT-mTOR but not of RAF-MEK-ERK signaling sensitizes melanoma cells to chemotherapy
    Niessner, H.
    Sinnberg, T.
    Lasithiotakis, K.
    Schittek, B.
    Kulms, D.
    Maczey, E.
    Gogel, J.
    Garbe, C.
    Meier, F.
    EXPERIMENTAL DERMATOLOGY, 2009, 18 (03) : 300 - 300
  • [34] The effect and mechanism of atorvastatin regulating PI3K-Akt-mTOR pathway on radiosensitivity of hepatocellular carcinoma cells
    Deng, Zhengzheng
    Guo, Jinjing
    Zhu, Zihao
    Qing, Qiancheng
    Wan, Dangting
    Lei, Pengyuan
    Liu, Qi
    Huang, Bo
    TOXICOLOGY RESEARCH, 2025, 14 (01)
  • [35] Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy
    Tewari, Devesh
    Patni, Pooja
    Bishayee, Anusha
    Sah, Archana N.
    Bishayee, Anupam
    SEMINARS IN CANCER BIOLOGY, 2022, 80 : 1 - 17
  • [36] Discovery of Chrysoeriol, a PI3K-AKT-mTOR Pathway Inhibitor with Potent Antitumor Activity against Human Multiple Myeloma Cells In Vitro (vol 30, pg 734, 2010)
    Yang, Yang
    Zhou, Xiaoxi
    Xiao, Min
    Hong, Zhenya
    Gong, Quan
    Jiang, Lijun
    Zhou, Jianfeng
    CURRENT MEDICAL SCIENCE, 2020, 40 (06): : 1203 - 1203
  • [37] Angiogenic Activity of Mesenchymal Stem Cells in Multiple Myeloma
    Wang, Xiaofang
    Zhang, Zhiqing
    Yao, Cheng
    CANCER INVESTIGATION, 2011, 29 (01) : 37 - 41
  • [38] Cyclophilin A as a downstream effector of PI3K/Akt signalling pathway in multiple myeloma cells
    Lin, Zuo-Lin
    Wu, Hsin-Jou
    Chen, Jin-An
    Lin, Kuo-Chih
    Hsu, Jung-Hsin
    CELL BIOCHEMISTRY AND FUNCTION, 2015, 33 (08) : 566 - 574
  • [39] The Role and Mechanism of PI3K/Akt/mTOR Signaling Pathway in Autophagy during Mesenchymal Stem Cells Directional Differentiation
    Gong, J.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 84 : 249 - 258
  • [40] Compartmentalized PI3K/Akt/mTOR Signaling in Living Cells
    Zhang, Jin
    FASEB JOURNAL, 2015, 29
12345