Targeting PI3K-AKT-mTOR Signaling in Multiple Myeloma Mesenchymal Stem Cells Mediates Antiproliferative Effect on Myeloma Cells

被引：0
|
作者：
Heinmann, Luca [1 ]
Noman, Helal Mohammed Mohammed Ahmed [1 ]
Moelers, Klara [1 ]
Nimmagadda, Subbaiah Chary [1 ]
Sun, Kaiyan [1 ]
Frank, Daria [1 ]
Korab, Hanna [2 ]
Wei, Lanying [3 ]
Baumann, Anja [2 ]
Poos, Alexandra [2 ]
Raab, Marc-Steffen [4 ,5 ]
Lenz, Georg [6 ]
Khandanpour, Cyrus [1 ]
机构：
[1] Univ Hosp Muenster, Dept Med A, Munster, Germany
[2] German Canc Res Ctr, Clin Cooperat Unit CCU Mol Hematol Oncol, Heidelberg, Germany
[3] Univ Hosp Muenster, Inst Med Informat, Munster, Germany
[4] Heidelberg Univ, German Canc Res Ctr DKFZ, Clin Cooperat Unit Mol Hematol Oncol, Heidelberg, Germany
[5] Heidelberg Univ, Dept Internal Med 5, Heidelberg, Germany
[6] Univ Hosp Muenster, Dept Med Hematol Oncol & Pneumol A, Munster, Germany
来源：
BLOOD | 2021年 / 138卷
关键词：
D O I：
10.1182/blood-2021-150413
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1600
引用
收藏
页数：3
相关论文
共 50 条
  • [21] β-Actin is a downstream effector of the PI3K/AKT signaling pathway in myeloma cells
    Ho, Yen-Peng
    Kuo, Chi-Wei
    Hsu, Yuan-Tong
    Huang, Yu-Shan
    Yew, Li-Ping
    Huang, Wei-Feng
    Lin, Kuo-Chih
    Hsu, Jung-Hsin
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2011, 348 (1-2) : 129 - 139
  • [22] β-Actin is a downstream effector of the PI3K/AKT signaling pathway in myeloma cells
    Yen-Peng Ho
    Chi-Wei Kuo
    Yuan-Tong Hsu
    Yu-Shan Huang
    Li-Ping Yew
    Wei-Feng Huang
    Kuo-Chih Lin
    Jung-Hsin Hsu
    Molecular and Cellular Biochemistry, 2011, 348 : 129 - 139
  • [23] PI3K-AKT-mTOR pathway is dominant over androgen receptor signaling in prostate cancer cells
    Kaarbo, Mari
    Mikkelsen, Oyvind Loveseter
    Malerod, Lene
    Qu, Su
    Lobert, Viola H.
    Akgul, Gulcan
    Halvorsen, Thomas
    Maelandsmo, Gunhild M.
    Saatcioglu, Fahri
    CELLULAR ONCOLOGY, 2010, 32 (1-2) : 11 - 27
  • [24] Resibufogenin inhibits the malignant characteristics of multiple myeloma cells by blocking the PI3K/Akt signaling pathway
    Zhou, Yan
    Hong, Zirui
    Jin, Keting
    Lin, Chenjun
    Xiang, Jingjing
    Ge, Hangping
    Zheng, Zhiyin
    Shen, Jianping
    Deng, Shu
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2022, 24 (01)
  • [25] Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases
    Eun Jung Choi
    Bong Jun Cho
    David J Lee
    Yeo Hyeon Hwang
    Sun Ha Chun
    Hans H Kim
    In Ah Kim
    BMC Cancer, 14
  • [26] Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises
    Yap, Timothy A.
    Garrett, Michelle D.
    Walton, Mike I.
    Raynaud, Florence
    de Bono, Johann S.
    Workman, Paul
    CURRENT OPINION IN PHARMACOLOGY, 2008, 8 (04) : 393 - 412
  • [27] Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases
    Choi, Eun Jung
    Cho, Bong Jun
    Lee, David J.
    Hwang, Yeo Hyeon
    Chun, Sun Ha
    Kim, Hans H.
    Kim, In Ah
    BMC CANCER, 2014, 14
  • [28] Targeting cancer stem cells in multiple myeloma
    Gunes, Emine Gulsen
    Gunes, Metin
    Yu, Jianhua
    Janakiram, Murali
    TRENDS IN CANCER, 2024, 10 (08) : 733 - 748
  • [29] Investigation of the Antitumor Effect of Targeting PI3K-AKT-mTOR Pathway and Histone Deacetylase Enzymes on Acute Myeloid Leukemia Cells
    Sansacar, Merve
    Sagir, Helin
    Akcok, Emel Gencer
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 : S294 - S294
  • [30] JTC-801 Suppresses Melanoma Cells Growth through the PI3K-Akt-mTOR Signaling Pathways
    Li, Jing
    Huang, Fei
    M S-MEDECINE SCIENCES, 2018, 34 : 8 - 14
12345