Antiproliferative activity of chelating N,O- and N,N-ruthenium(II) arene functionalised poly(propyleneimine) dendrimer scaffolds

被引：145
|
作者：
Govender, Preshendren [1 ]
Renfrew, Anna K. [2 ]
Clavel, Catherine M. [2 ]
Dyson, Paul J. [2 ]
Therrien, Bruno [3 ]
Smith, Gregory S. [1 ]
机构：
[1] Univ Cape Town, Dept Chem, ZA-7701 Cape Town, South Africa
[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
[3] Univ Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland
来源：
DALTON TRANSACTIONS | 2011年 / 40卷 / 05期
基金：
英国医学研究理事会; 新加坡国家研究基金会;
关键词：
RUTHENIUM COMPLEXES; ANTICANCER ACTIVITY; MOLECULAR-STRUCTURE; CATALYTIC-ACTIVITY; RUTHENIUM(II)-ARENE COMPLEXES; NICKEL-CATALYSTS; METAL-COMPLEXES; ANTITUMOR DRUG; IN-VITRO; DNA;
D O I：
10.1039/c0dt00761g
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Chelating neutral (N,O) and cationic (N,N) first-and second-generation ruthenium(II) arene metallodendrimers based on poly(propyleneimine) dendrimer scaffolds were obtained from dinuclear arene ruthenium precursors by reactions with salicylaldimine and iminopyridyl dendritic ligands, respectively. The N, N cationic complexes were isolated as hexafluorophosphate salts and were characterised by NMR and IR spectroscopy, and MALDI-TOF mass spectrometry. Related mononuclear complexes were obtained in a similar manner and their molecular structures have been determined by X-ray diffraction analysis. The cytotoxicities of the mono-and multinuclear complexes were established using A2780 and A2780cisR human ovarian carcinoma cancer cell lines.
引用
收藏
页码：1158 / 1167
页数：10
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