Antiproliferative activity of chelating N,O- and N,N-ruthenium(II) arene functionalised poly(propyleneimine) dendrimer scaffolds

被引：145

作者：

Govender, Preshendren ^{[1
]}

Renfrew, Anna K. ^{[2
]}

Clavel, Catherine M. ^{[2
]}

Dyson, Paul J. ^{[2
]}

Therrien, Bruno ^{[3
]}

Smith, Gregory S. ^{[1
]}

机构：

[1] Univ Cape Town, Dept Chem, ZA-7701 Cape Town, South Africa

[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

[3] Univ Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland

来源：

DALTON TRANSACTIONS | 2011年 / 40卷 / 05期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

RUTHENIUM COMPLEXES; ANTICANCER ACTIVITY; MOLECULAR-STRUCTURE; CATALYTIC-ACTIVITY; RUTHENIUM(II)-ARENE COMPLEXES; NICKEL-CATALYSTS; METAL-COMPLEXES; ANTITUMOR DRUG; IN-VITRO; DNA;

D O I：

10.1039/c0dt00761g

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chelating neutral (N,O) and cationic (N,N) first-and second-generation ruthenium(II) arene metallodendrimers based on poly(propyleneimine) dendrimer scaffolds were obtained from dinuclear arene ruthenium precursors by reactions with salicylaldimine and iminopyridyl dendritic ligands, respectively. The N, N cationic complexes were isolated as hexafluorophosphate salts and were characterised by NMR and IR spectroscopy, and MALDI-TOF mass spectrometry. Related mononuclear complexes were obtained in a similar manner and their molecular structures have been determined by X-ray diffraction analysis. The cytotoxicities of the mono-and multinuclear complexes were established using A2780 and A2780cisR human ovarian carcinoma cancer cell lines.

引用

页码：1158 / 1167

页数：10

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