The G-Protein Biased Mu Opioid Receptor Ligand SR17108 Produces Less Tolerance and Dependence Relative to Morphine

被引:0
|
作者
Grim, Travis [1 ]
Schmid, Cullen [1 ]
Pantouli, Fani [1 ]
Kennedy, Nicole [1 ]
McFague, Nina [1 ]
Cameron, Michael [1 ]
Bannister, Thomas [1 ]
Bohn, Laura [1 ]
机构
[1] Scripps Res, Jupiter, FL USA
关键词
Opioid Abuse; Opioid Dependence; Opioid Tolerance;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
M271
引用
收藏
页码:S220 / S221
页数:2
相关论文
共 50 条
  • [21] THE EFFECT OF A G-PROTEIN BIASED LIGAND, TRV130, ON OPIOID-INDUCED CONSTIPATION
    Jacob, Joanna C.
    David, Bethany
    Khan, Aliyeen
    Dewey, William L.
    Akbarali, Hamid I.
    GASTROENTEROLOGY, 2018, 154 (06) : S758 - S758
  • [22] Novel Application for G Protein-Biased Mu Opioid Receptor Agonists in Opioid Relapse Prevention
    Fakira, Amanda K.
    Devi, Lakshmi A.
    Kennedy, Pamela J.
    BIOLOGICAL PSYCHIATRY, 2020, 88 (12) : 896 - 897
  • [23] Ligand interaction, binding site and G protein activation of the mu opioid receptor
    Cui, Xu
    Yeliseev, Alexei
    Liu, Renyu
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 702 (1-3) : 309 - 315
  • [24] Mechanisms of mu opioid receptor/G-protein desensitization in brain by chronic heroin administration
    Maher, CE
    Martin, TJ
    Childers, SR
    LIFE SCIENCES, 2005, 77 (10) : 1140 - 1154
  • [25] Region-dependent attenuation of μ opioid receptor-mediated G-protein activation in mouse CNS as a function of morphine tolerance
    Sim-Selley, L. J.
    Scoggins, K. L.
    Cassidy, M. P.
    Smith, L. A.
    Dewey, W. L.
    Smith, F. L.
    Selley, D. E.
    BRITISH JOURNAL OF PHARMACOLOGY, 2007, 151 (08) : 1324 - 1333
  • [26] Pharmacological Characters of Oliceridine, a μ-Opioid Receptor G-Protein-Biased Ligand in Mice
    Liang, De-Yong
    Li, Wen-Wu
    Nwaneshiudu, Chinwe
    Irvine, Karen-Amanda
    Clark, J. David
    ANESTHESIA AND ANALGESIA, 2019, 129 (05): : 1414 - 1421
  • [27] Effects of a highly G Protein-Biased Mu Opioid Receptor Agonist, SR-17018, in Non-human Primates
    Ko, Mei Chuan
    Ding, Huiping
    Kiguchi, Norikazu
    Zhang, Dehui
    Zhang, Yanan
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2023, 385
  • [28] A HIGHLY G PROTEIN-BIASED MU OPIOID RECEPTOR AGONIST, SR-17018, HAS LOW IN VIVO EFFICACY IN PRIMATES
    Ko, Mei-Chuan
    Ding, Huiping
    Kiguchi, Norikazu
    Zhang, Dehui
    Zhang, Yanan
    DRUG AND ALCOHOL DEPENDENCE, 2024, 260
  • [29] Increased MU-opioid receptor mediated G-protein activation in mice with diabetes mellitus
    Cheng, EY
    Pham, NM
    Mizoguchi, H
    Narita, M
    Tseng, LF
    ANESTHESIOLOGY, 1999, : U12 - U12
  • [30] Increase mu-opioid receptor mediate G-protein activation in mice with diabetes mellitus
    Chng, EY
    Phan, NM
    Mizoguchi, H
    Narita, M
    Tseng, LF
    ANESTHESIOLOGY, 1999, 91 (3A) : U380 - U380