The G-Protein Biased Mu Opioid Receptor Ligand SR17108 Produces Less Tolerance and Dependence Relative to Morphine

被引:0
|
作者
Grim, Travis [1 ]
Schmid, Cullen [1 ]
Pantouli, Fani [1 ]
Kennedy, Nicole [1 ]
McFague, Nina [1 ]
Cameron, Michael [1 ]
Bannister, Thomas [1 ]
Bohn, Laura [1 ]
机构
[1] Scripps Res, Jupiter, FL USA
关键词
Opioid Abuse; Opioid Dependence; Opioid Tolerance;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
M271
引用
收藏
页码:S220 / S221
页数:2
相关论文
共 50 条
  • [11] A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal
    Travis W. Grim
    Cullen L. Schmid
    Edward L. Stahl
    Fani Pantouli
    Jo-Hao Ho
    Agnes Acevedo-Canabal
    Nicole M. Kennedy
    Michael D. Cameron
    Thomas D. Bannister
    Laura M. Bohn
    Neuropsychopharmacology, 2020, 45 : 416 - 425
  • [12] Discovery and Structural Explorations of G-Protein Biased μ-Opioid Receptor Agonists
    Li, Xiang
    Guo, Yanhao
    Li, Jing
    Yu, Zixing
    Cheng, Jingchao
    Ren, Fengxia
    Jia, Hongxin
    Zhang, Yatong
    Cui, Shiqiang
    Zhang, Tao
    Shi, Weiguo
    CHEMMEDCHEM, 2022, 17 (24)
  • [13] Some effects of putative G-protein biased mu-opioid receptor agonists in male rhesus monkeys
    Cornelissen, Jeremy C.
    Blough, Bruce E.
    Bohn, Laura M.
    Negus, S. Stevens
    Banks, Matthew L.
    BEHAVIOURAL PHARMACOLOGY, 2021, 32 (05): : 453 - 458
  • [14] The contributions of G-protein coupled receptor signalling to opioid dependence
    van Tonder, I.
    SOUTH AFRICAN JOURNAL OF PSYCHIATRY, 2013, 19 (03) : 110 - 110
  • [15] Self-administration of G-protein biased mu opioid agonists in nonhuman primates
    Paronis, Carol
    George, Kristen E.
    Bow, Eric W.
    Gutman, Eugene S.
    Sulima, Agnieszka
    Rice, Kenner
    Jacobson, Arthur
    Bergman, Jack
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2023, 385
  • [16] The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats
    Zamarripa, C. Austin
    Edwards, Shelley R.
    Qureshi, Hina N.
    Yi, John N.
    Blough, Bruce E.
    Freeman, Kevin B.
    DRUG AND ALCOHOL DEPENDENCE, 2018, 192 : 158 - 162
  • [17] Opioid peptide receptor studies. 16. Chronic morphine alters G-protein function in cells expressing the cloned mu opioid receptor
    Xu, H
    Lu, YF
    Rothman, RB
    SYNAPSE, 2003, 47 (01) : 1 - 9
  • [18] Disulfiram Abrogates Morphine Tolerance-A Possible Role of μ-Opioid Receptor-Related G-Protein Activation in the Striatum
    de Corde-Skurska, Anna
    Krzascik, Pawel
    Lesniak, Anna
    Sacharczuk, Mariusz
    Nagraba, Lukasz
    Bujalska-Zadrozny, Magdalena
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (08)
  • [19] Effect of reduced mu opioid receptor density on the relative efficacy of full and partial agonists for G-protein activation.
    Rorrer, WK
    Selley, DE
    FASEB JOURNAL, 2000, 14 (08): : A1380 - A1380
  • [20] Binding Pathways of a G-Protein Biased μ-opioid Receptor agonist under Clinical Evaluation
    Schneider, Sebastian
    Provasi, Davide
    Filizola, Marta
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 591A - 591A