The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression

被引：132
|
作者：
Houthuijzen, J. M. [1 ]
Daenen, L. G. M. [1 ]
Roodhart, J. M. L. [1 ]
Voest, E. E. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Med Oncol, NL-3508 GA Utrecht, Netherlands
来源：
BRITISH JOURNAL OF CANCER | 2012年 / 106卷 / 12期
关键词：
mesenchymal stem cells; tumour progression; drug resistance; chemotherapy resistance; ENDOTHELIAL-CELLS; LEUKEMIA CELLS; APOPTOSIS; MICROENVIRONMENT; METABOLISM; SURVIVAL; STROMA; ACID;
D O I：
10.1038/bjc.2012.201
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It is becoming increasingly clear that the tumour microenvironment has a very important role in tumour progression and drug resistance. Many different cell types within the tumour stroma have an effect on tumour progression either in a positive or in a negative way. Mesenchymal stem cells (MSCs) are a distinct population of cells that have been linked with tumour growth. Mesenchymal stem cells can home to tumours where they modulate the immune system and facilitate tumour growth, angiogenesis and metastasis. Recent studies have shown that MSCs also have an important role in the resistance to various anti-cancer drugs. This mini-review provides an overview of the functional properties of MSCs in tumour progression and drug resistance. British Journal of Cancer (2012) 106, 1901-1906. doi:10.1038/bjc.2012.201 www.bjcancer.com Published online 17 May 2012 (C) 2012 Cancer Research UK
引用
收藏
页码：1901 / 1906
页数：6
相关论文
共 50 条
  • [31] DDX53/miRNAs network regulates stemness and anti-cancer drug resistance by activating autophagy in cancer stem cells
    Kim, Youngmi
    Park, Sung Taek
    Lee, Jae Jun
    FASEB JOURNAL, 2018, 32 (01):
  • [32] Anti-Cancer Phytometabolites Targeting Cancer Stem Cells
    Torquato, Heron F. V.
    Goettert, Marcia I.
    Justo, Giselle Z.
    Paredes-Gamero, Edgar J.
    CURRENT GENOMICS, 2017, 18 (02) : 156 - 174
  • [33] Lipid-related anti-cancer drug resistance of lung adenocarcinoma cells
    Gruending, Anna
    Martinez-Delgado, Beatriz
    Liu, Bin
    Deluca, David
    Wrenger, Sabine
    Welte, Tobias
    Janciauskiene, Sabina
    EUROPEAN RESPIRATORY JOURNAL, 2021, 58
  • [34] ROLE OF HEMOPERFUSION IN ANTI-CANCER DRUG REMOVAL
    WINCHESTER, J
    RAHMAN, A
    BREGMAN, H
    MORTENSEN, LM
    GELFAND, MC
    SCHEIN, PS
    SCHREINER, GE
    ARTIFICIAL ORGANS, 1979, 3 (04) : 400 - 400
  • [35] Small extracellular vesicles derived from mesenchymal stem/stromal cells as drug-delivery tools for anti-cancer drugs
    Klimova, Daniela
    Pastorakova, Andrea
    Tomka, Miroslav
    Altaner, Cestmir
    Repiska, Vanda
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2024, 99
  • [36] The role of glycosphingolipids in the formation of cancer stem cells and drug resistance
    Gupta, Vineet
    Patwardhan, Gauri Anand
    Gu, Xin
    Rowan, Brian
    Jazwinski, Michal
    Liu, Yong Yu
    CANCER RESEARCH, 2010, 70
  • [37] The Role of Tumor Stem Cells in Colorectal Cancer Drug Resistance
    Zhong, Chen
    Wang, Guojuan
    Guo, Min
    Zhu, Naicheng
    Chen, Xiudan
    Yan, Yuwei
    Li, Nanxin
    Yu, Wenyan
    CANCER CONTROL, 2024, 31
  • [38] Targeting cancer stem cells with platinum anti-cancer drug-incorporated polymeric micelles
    Wang, M.
    Miura, Y.
    Cabral, H.
    Nishiyama, N.
    Kataoka, K.
    EUROPEAN JOURNAL OF CANCER, 2013, 49 : S152 - S152
  • [39] Molecular chess? Hallmarks of anti-cancer drug resistance!
    Cree, Ian A.
    Charlton, Peter
    BMC CANCER, 2017, 17
  • [40] The dual role of mesenchymal stem cells in tumor progression
    Freitas Gomes, Celia Maria
    STEM CELL RESEARCH & THERAPY, 2013, 4
12345