The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression

被引：132
|
作者：
Houthuijzen, J. M. [1 ]
Daenen, L. G. M. [1 ]
Roodhart, J. M. L. [1 ]
Voest, E. E. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Med Oncol, NL-3508 GA Utrecht, Netherlands
来源：
BRITISH JOURNAL OF CANCER | 2012年 / 106卷 / 12期
关键词：
mesenchymal stem cells; tumour progression; drug resistance; chemotherapy resistance; ENDOTHELIAL-CELLS; LEUKEMIA CELLS; APOPTOSIS; MICROENVIRONMENT; METABOLISM; SURVIVAL; STROMA; ACID;
D O I：
10.1038/bjc.2012.201
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It is becoming increasingly clear that the tumour microenvironment has a very important role in tumour progression and drug resistance. Many different cell types within the tumour stroma have an effect on tumour progression either in a positive or in a negative way. Mesenchymal stem cells (MSCs) are a distinct population of cells that have been linked with tumour growth. Mesenchymal stem cells can home to tumours where they modulate the immune system and facilitate tumour growth, angiogenesis and metastasis. Recent studies have shown that MSCs also have an important role in the resistance to various anti-cancer drugs. This mini-review provides an overview of the functional properties of MSCs in tumour progression and drug resistance. British Journal of Cancer (2012) 106, 1901-1906. doi:10.1038/bjc.2012.201 www.bjcancer.com Published online 17 May 2012 (C) 2012 Cancer Research UK
引用
收藏
页码：1901 / 1906
页数：6
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