Synthesis of the C1-C20 and C15-C27 Segments of Aplyronine A

被引：18

作者：

Hong, Wan Pyo ^{[1
]}

Noshi, Mohammad N. ^{[1
]}

El-Awa, Ahmad ^{[1
]}

Fuchs, Philip L. ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 24期

关键词：

POTENT ANTITUMOR SUBSTANCE; MARINE MACROLIDE SYNTHESIS; ORGANIC-SYNTHESIS; STEREOCONTROLLED SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ALDEHYDES; CONVERSION; SULFONES; ORIGIN; STEREOTETRADS;

D O I：

10.1021/ol2024746

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of C1-C20 and C15-C27 segments of Aplyronine A is described. Oxidative cleavage of cyclic vinyl sulfones has been used to prepare key fragments of Aplyronine A. Key precursors are united by Horner-Wadsworth-Emmons and Julia-Kociensky olefination for the respective elaboration of the C1-C20 and C15-C27 segments.

引用

页码：6342 / 6345

页数：4

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