Catalytic Asymmetric Synthesis of the C1-C15 Segment of Spirastrellolide A

被引：4

作者：

Sahara, Yui ^{[1
]}

Cui, Jin ^{[1
]}

Furutachi, Makoto ^{[1
]}

Chen, Jingbo ^{[1
]}

Watanabe, Takumi ^{[1
]}

Shibasaki, Masakatsu ^{[1
]}

机构：

[1] Inst Microbial Chem BIKAKEN, Shinagawa Ku, 3-14-23 Kamiosaki, Tokyo 1410021, Japan

来源：

SYNTHESIS-STUTTGART | 2017年 / 49卷 / 01期

关键词：

spirastrellolide A; catalytic asymmetric synthesis; catalytic enantioselective thioamide-aldol reaction; natural product synthesis; PP2A inhibitor; F METHYL-ESTER; 2ND-GENERATION TOTAL-SYNTHESIS; PROTEIN PHOSPHATASE 2A; ANION RELAY CHEMISTRY; ALDOL REACTION; PART; FRAGMENT; SUBUNIT; (+)-SPIRASTRELLOLIDE; TRIOXADISPIROKETAL;

D O I：

10.1055/s-0036-1588068

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic asymmetric synthesis of the C1-C15 fragment of spirastrellolide A, a naturally occurring PP2A inhibitor, was achieved. To construct the 1,3-polyol system in a stereodefined manner, we took advantage of an iterative aldol strategy comprising the catalytic asymmetric thioamide-aldol reaction, and a diastereoselective crotylation process. A potential segment for the total synthesis of spirastrellolide A was thus accessed through a 14-step procedure.

引用

页码：69 / 75

页数：7

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