Pregnancy in a Woman With Congenital Generalized Lipodystrophy

被引：25
|
作者：
Maguire, Marcy [1 ]
Lungu, Andrea
Gorden, Phillip
Cochran, Elaine
Stratton, Pamela
机构：
[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20814 USA
来源：
OBSTETRICS AND GYNECOLOGY | 2012年 / 119卷 / 02期
关键词：
HUMAN LEPTIN; OBESITY; WOMEN;
D O I：
10.1097/AOG.0b013e31822cecf7
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
BACKGROUND: Congenital generalized lipodystrophy is a rare disorder characterized by scant adipose tissue, profound leptin deficiency, and severe insulin resistance, resulting in multiple metabolic derangements, including hyperandrogenism, anovulation, and impaired fecundity. CASE: A young woman with congenital generalized lipodystrophy receiving leptin therapy experienced menarche, conceived spontaneously, and delivered a liveborn male neonate. CONCLUSION: Adipose tissue is important to normal female reproductive function. Leptin in particular appears to play a key role in adipose-mediated regulation of fertility. (Obstet Gynecol 2012;119:452-5) DOI: 10.1097/AOG.0b013e31822cecf7
引用
收藏
页码：452 / 455
页数：4
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