Pregnancy in a Woman With Congenital Generalized Lipodystrophy

被引：25
|
作者：
Maguire, Marcy [1 ]
Lungu, Andrea
Gorden, Phillip
Cochran, Elaine
Stratton, Pamela
机构：
[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20814 USA
来源：
OBSTETRICS AND GYNECOLOGY | 2012年 / 119卷 / 02期
关键词：
HUMAN LEPTIN; OBESITY; WOMEN;
D O I：
10.1097/AOG.0b013e31822cecf7
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
BACKGROUND: Congenital generalized lipodystrophy is a rare disorder characterized by scant adipose tissue, profound leptin deficiency, and severe insulin resistance, resulting in multiple metabolic derangements, including hyperandrogenism, anovulation, and impaired fecundity. CASE: A young woman with congenital generalized lipodystrophy receiving leptin therapy experienced menarche, conceived spontaneously, and delivered a liveborn male neonate. CONCLUSION: Adipose tissue is important to normal female reproductive function. Leptin in particular appears to play a key role in adipose-mediated regulation of fertility. (Obstet Gynecol 2012;119:452-5) DOI: 10.1097/AOG.0b013e31822cecf7
引用
收藏
页码：452 / 455
页数：4
相关论文
共 50 条
  • [11] Genetic basis of congenital generalized lipodystrophy
    Agarwal, AK
    Barnes, RI
    Garg, A
    INTERNATIONAL JOURNAL OF OBESITY, 2004, 28 (02) : 336 - 339
  • [12] A Rare Case of Congenital Generalized Lipodystrophy
    Chalipat, Shiji
    Avuthu, Om Prasanth Reddy
    Sindhura, P.
    V. Mane, Shailaja
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (07)
  • [13] Molecular basis of congenital generalized lipodystrophy
    Garg, A
    FASEB JOURNAL, 2003, 17 (04): : A364 - A364
  • [14] A case of cholangiocarcinoma in congenital generalized lipodystrophy
    Aizawa-Abe, Megumi
    Yamamoto-Kataoka, Sachiko
    Kusakabe, Toru
    Aotani, Daisuke
    Sakai, Takeru
    Miyazawa, Takashi
    Ebihara, Ken
    Hosoda, Kiminori
    Nakao, Kazuwa
    ENDOCRINE JOURNAL, 2010, 57 : S428 - S428
  • [15] Generalized lipodystrophy, congenital and acquired (lipoatrophy)
    Seip, M
    Trygstad, O
    ACTA PAEDIATRICA, 1996, 85 : 2 - 28
  • [16] Studies of insulin resistance in congenital generalized lipodystrophy
    Sovik, O
    Vestergaard, H
    Trygstad, O
    Pedersen, O
    ACTA PAEDIATRICA, 1996, 85 : 29 - 37
  • [17] Congenital generalized congenital lipodystrophy type 2 in the Moche culture
    Purizaca-Rosillo, Nelson
    Correa-Trigoso, Denis E.
    Bazan, Guillermo Gayoso
    Candelo, Estephania
    Pachajoa, Harry
    Rodriguez, Carlos Armando
    REVISTA DEL CUERPO MEDICO DEL HOSPITAL NACIONAL ALMANZOR AGUINAGA ASENJO, 2023, 16 (02):
  • [18] Congenital generalized lipodystrophy family with myopathic involvement
    Sevindik, M. Sohtaoglu
    Akalin, M. A.
    Tunckale, A.
    EUROPEAN JOURNAL OF NEUROLOGY, 2015, 22 : 719 - 719
  • [19] METRELEPTIN USE IN CHILDREN WITH CONGENITAL GENERALIZED LIPODYSTROPHY
    Felipe, Dania L.
    Zambrano, Regina
    Cochran, Elaine
    Brown, Rebecca
    Garg, Abhimanyu
    HORMONE RESEARCH IN PAEDIATRICS, 2017, 88 : 577 - 577
  • [20] Severe islet amyloidosis in congenital generalized lipodystrophy
    Garg, A
    Chandalia, M
    Vuitch, F
    DIABETES CARE, 1996, 19 (01) : 28 - 31
12345