Pregnancy in a Woman With Congenital Generalized Lipodystrophy

被引：25
|
作者：
Maguire, Marcy [1 ]
Lungu, Andrea
Gorden, Phillip
Cochran, Elaine
Stratton, Pamela
机构：
[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20814 USA
来源：
OBSTETRICS AND GYNECOLOGY | 2012年 / 119卷 / 02期
关键词：
HUMAN LEPTIN; OBESITY; WOMEN;
D O I：
10.1097/AOG.0b013e31822cecf7
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
BACKGROUND: Congenital generalized lipodystrophy is a rare disorder characterized by scant adipose tissue, profound leptin deficiency, and severe insulin resistance, resulting in multiple metabolic derangements, including hyperandrogenism, anovulation, and impaired fecundity. CASE: A young woman with congenital generalized lipodystrophy receiving leptin therapy experienced menarche, conceived spontaneously, and delivered a liveborn male neonate. CONCLUSION: Adipose tissue is important to normal female reproductive function. Leptin in particular appears to play a key role in adipose-mediated regulation of fertility. (Obstet Gynecol 2012;119:452-5) DOI: 10.1097/AOG.0b013e31822cecf7
引用
收藏
页码：452 / 455
页数：4
相关论文
共 50 条
  • [1] Congenital generalized lipodystrophy
    Kerr, Holly
    Bossenbroek, Nicole
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2007, 56 (02) : AB156 - AB156
  • [2] CONGENITAL GENERALIZED LIPODYSTROPHY
    STARKOVA, NT
    TERAPEVTICHESKII ARKHIV, 1979, 51 (10) : 53 - 57
  • [3] CONGENITAL GENERALIZED LIPODYSTROPHY
    NAJJAR, SS
    SALEM, GM
    IDRISS, ZH
    ACTA PAEDIATRICA SCANDINAVICA, 1975, 64 (02): : 273 - 279
  • [4] GENERALIZED LIPODYSTROPHY AND PREGNANCY
    STURLEY, RH
    STIRLING, C
    RECKLESS, JPD
    BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1994, 101 (08): : 719 - 720
  • [5] Pregnancy in a Woman With Congenital Generalized Lipodystrophy: Leptin's Vital Role in Reproduction (vol 119, pg 452, 2012)
    Maguire, M.
    Lungu, A.
    Gorden, P.
    Cochran, E.
    Stratton, P.
    OBSTETRICS AND GYNECOLOGY, 2013, 122 (01): : 160 - 160
  • [6] Congenital generalized lipodystrophy in Taiwan
    Hsu, Rai-Hseng
    Lin, Wei-De
    Chao, Mei-Chyn
    Hsiao, Hui-Pin
    Wong, Siew-Lee
    Chiu, Pao-Chin
    Chu, Shao-Yin
    Ke, Yu-Yuan
    Lau, Beng-Huat
    Chien, Yin-Hsiu
    Hwu, Wuh-Liang
    Tsai, Fuu-Jen
    Wang, Chung-Hsing
    Lee, Ni-Chung
    JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2019, 118 (01) : 142 - 147
  • [7] CONGENITAL TYPE OF GENERALIZED LIPODYSTROPHY
    CHOREMIS, KB
    CONSTANT.B
    KATTAMIS, CA
    ACTA PAEDIATRICA SCANDINAVICA, 1965, 54 (02): : 175 - &
  • [8] Tirzepatide for Congenital Generalized Lipodystrophy
    Ten, Svetlana
    Bhangoo, Amrit
    Buettner, Christoph
    NEW ENGLAND JOURNAL OF MEDICINE, 2025, 392 (07): : 717 - 719
  • [9] Genetic basis of congenital generalized lipodystrophy
    A K Agarwal
    R I Barnes
    A Garg
    International Journal of Obesity, 2004, 28 : 336 - 339
  • [10] POSTMORTEM FINDINGS IN CONGENITAL GENERALIZED LIPODYSTROPHY
    CHANDALIA, M
    GARG, A
    VUITCH, F
    NIZZI, F
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (10): : 3077 - 3081
12345