Generation of two iPSC lines, (ICGi015-A and ICGi015-B), by reprogramming peripheral blood mononuclear cells from a patient with Parkinson's disease

被引：2
|
作者：
Sharipova, D. V. [1 ,2 ,3 ]
Kovalenko, V. R. [1 ]
Bairamova, E. M. [1 ,3 ]
Vartanova, V. A. [1 ,3 ]
Grigor'eva, E. V. [1 ,2 ,3 ]
Vyatkin, Y. V. [3 ,5 ,6 ]
Khabarova, E. A. [4 ]
Rzaev, D. A. [4 ]
Zakian, S. M. [1 ,2 ,3 ]
Medvedev, S. P. [1 ,2 ,3 ]
机构：
[1] Russian Acad Sci, Siberian Branch, Fed Res Ctr, Inst Cytol & Genet, Novosibirsk, Russia
[2] Minist Hlth Russian Federat, EN Meshalkin Natl Med Res Ctr, Novosibirsk, Russia
[3] Novosibirsk State Univ, Novosibirsk, Russia
[4] Fed Neurosurg Ctr, Novosibirsk, Russia
[5] AcademGene LLC, Novosibirsk, Russia
[6] St Laurent Inst, Woburn, MA USA
来源：
STEM CELL RESEARCH | 2019年 / 41卷
基金：
俄罗斯科学基金会;
关键词：
D O I：
10.1016/j.scr.2019.101652
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Studying Parkinson's disease (PD), one of the most common neurodegenerative disorders worldwide, requires different model systems, including patient-specific induced pluripotent stem cell lines. With the help of non-integrating episomal vectors the iPSC lines ICGi015-A and ICGi015-B were generated from blood mononuclear cells of PD patient, carrying three SNPs, associated with PD development. The obtained iPSC lines express pluripotency markers and demonstrate the ability to in vitro differentiate into the three germ layers. These cell lines may be useful for studying molecular mechanisms of PD and for drug screening.
引用
收藏
页数：5
相关论文
共 50 条
  • [11] Generation of an Induced Pluripotent Stem Cell Line, ICGi043-A, by Reprogramming Peripheral Blood Mononuclear Cells from a Parkinson's Disease Patient with p.G2019S Mutation in the LRRK2 Gene
    Grigor'eva, E. V.
    Pavlova, S. V.
    Malakhova, A. A.
    Yarkova, E. S.
    Sorogina, D. A.
    Minina, J. M.
    Miliukhina, I. V.
    Nikolaev, M. A.
    Pchelina, S. N.
    Medvedev, S. P.
    Zakian, S. M.
    RUSSIAN JOURNAL OF DEVELOPMENTAL BIOLOGY, 2023, 54 (01) : 72 - 79
  • [12] Generation of an Induced Pluripotent Stem Cell Line, ICGi042-A, by Reprogramming Peripheral Blood Mononuclear Cells from a Parkinson's Disease Patient with c.1000G>A Mutation in the LRRK2 Gene
    Grigor'eva, E. V.
    Pavlova, S. V.
    Malakhova, A. A.
    Medvedev, S. P.
    Minina, J. M.
    Vyatkin, Y. V.
    Khabarova, E. A.
    Rzaev, J. A.
    Kovalenko, L. V.
    Zakian, S. M.
    RUSSIAN JOURNAL OF DEVELOPMENTAL BIOLOGY, 2023, 54 (01) : 80 - 87
  • [13] Generation of two iPSC lines (ICGi008-A and ICGi008-B) from skin fibroblasts of a patient with early-onset Alzheimer's disease caused by London familial APP mutation (V717I)
    Grigor'eva, E., V
    Malankhanova, T. B.
    Ustyantseva, E., I
    Minina, J. M.
    Redina, O. E.
    Morozov, V. V.
    Shevela, A., I
    Zakian, S. M.
    Medvedev, S. P.
    STEM CELL RESEARCH, 2019, 36
  • [14] A protocol for the generation of patient-specific iPSC lines from peripheral blood mononuclear cells
    Gao, Langping
    Wang, Fangqin
    Wang, Yan
    Hu, Lidan
    Mao, Jianhua
    STAR PROTOCOLS, 2022, 3 (03):
  • [15] Establishment of an induced pluripotent stem cell line (ICGi026-A) from peripheral blood mononuclear cells of a patient with fragile X syndrome
    Gridina, M. M.
    Orlova, P. A.
    Minina, J. M.
    Shitik, E. M.
    Lemskaya, N. A.
    Grishchenko, I., V
    Dolskiy, A. A.
    Shorina, A. R.
    Maksimova, Y., V
    Yudkin, D., V
    Serov, O. L.
    STEM CELL RESEARCH, 2020, 49
  • [16] Generation of two induced pluripotent stem cell lines from peripheral blood mononuclear cells of a patient with Wilson's disease
    Malakhova, A. A.
    Grigor'eva, E., V
    Vasilyeva, O. Yu
    Zhigalina, D., I
    Skryabin, N. A.
    Sivtcev, A. A.
    Kolesnikov, N. A.
    Bueverov, A. O.
    Lebedev, I. N.
    Bogomolov, P. O.
    Zakian, S. M.
    STEM CELL RESEARCH, 2020, 47
  • [17] Generation of iPSC lines from peripheral blood mononuclear cells from five healthy donors
    Vlahos, Katerina
    Sourris, Koula
    Kuah, Jia Yi
    Graham, Alison
    Suter, Annabelle
    Howden, Sara E.
    Stanley, Edouard G.
    Elefanty, Andrew G.
    STEM CELL RESEARCH, 2023, 69
  • [18] Generation of iPSC lines from peripheral blood mononuclear cells from 5 healthy adults
    Vlahos, Katerina
    Sourris, Koula
    Mayberry, Robyn
    McDonald, Penelope
    Bruveris, Freya F.
    Schiesser, Jacqueline V.
    Bozaoglu, Kiymet
    Lockhart, Paul J.
    Stanley, Edouard G.
    Elefanty, Andrew G.
    STEM CELL RESEARCH, 2019, 34
  • [19] Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease
    Baek, Daye
    Lee, Kun-Gu
    Sohn, Hee-Young
    Park, Jung Hyun
    Lee, Hye-Kyung
    Bayarsaikhan, Govigerel
    Yoo, Sang-Won
    Lee, Bonghee
    Kim, Joong-Seok
    Koh, Young Ho
    Kwon, Munjin
    STEM CELL RESEARCH, 2024, 76
  • [20] Generation of an induced pluripotent stem cell line, ICGi014-A, by reprogramming peripheral blood mononuclear cells from a patient with homozygous D90A mutation in SOD1 causing Amyotrophic lateral sclerosis
    Ustyantseva, E., I
    Medvedev, S. P.
    Vetchinova, A. S.
    Illarioshkin, S. N.
    Leonov, S., V
    Zakian, S. M.
    STEM CELL RESEARCH, 2020, 42
12345