Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-α

被引：37

作者：

Takano-Ishikawa, Y ^{[1
]}

Goto, M ^{[1
]}

Yamaki, K ^{[1
]}

机构：

[1] Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan

来源：

PHYTOTHERAPY RESEARCH | 2003年 / 17卷 / 10期

关键词：

flavonoids; E-selectin; tumor necrosis factor; human umbilical vein endothelial cell;

D O I：

10.1002/ptr.1371

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present study investigates the suppressive effect of flavonoids on TNF-alpha-stimulated E-selectin expression on HUVECs by carrying out a comparative examination of the 37 flavonoids. Several flavonoids: fisetin, luteolin and apigenin (subclass of flavone), kaempferol and quercetin (flavonols), eriodictyol (flavanones), genistein (isoflavones) and butein (chalcone) exhibit the inhibitory effects. Considerations to the structure of flavonoids, the C2-C3 double bond of C-ring and 4-oxo functional group are essential for their inhibition activities. These results help to explain the pharmacological efficacy of flavonoids as anti-inflammatory compounds. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：1224 / 1227

页数：4

共 50 条

[31] SELAGINELLA FLAVONOIDS SUPPRESS VCAM-1 AND E-SELECTIN EXPRESSION IN TNF-α-TREATED HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS BY BLOCKING NF-κB ACTIVATION
Wang, X. L.
Liu, C. X.
Zheng, X. K.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2018, 122 : 53 - 53
[32] Tumour necrosis factor-α gene expression and production in human umbilical arterial endothelial cells
Neuhaus, T
Totzke, G
Gruenewad, E
Juesten, HP
Sachinidis, A
Vetter, H
Ko, Y
CLINICAL SCIENCE, 2000, 98 (04) : 461 - 470
[33] Eupatilin protects against tumor necrosis factor-α-mediated inflammation inhuman umbilical vein endothelial cells
Yu, Kai
Li, Xi-Ming
Xu, Xiao-Lei
Zhang, Ru-Yan
Cong, Hong-Liang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (12): : 22191 - 22197
[34] An oligonucleotide decoy for nuclear factor-κB inhibits tumor necrosis factor-α-induced human umbilical cord vein endothelial cell tissue factor expression in vitro
Wang, LL
Wei, WN
Hu, Y
Song, SJ
Yan, Z
BLOOD COAGULATION & FIBRINOLYSIS, 2004, 15 (06) : 483 - 490
[35] cDNA microarray analysis of gene expression profile in tumor necrosis factor-α-stimulated human aortic endothelial cells
Chen, YH
Chen, YL
Chen, JW
Lin, SJ
ATHEROSCLEROSIS SUPPLEMENTS, 2003, 4 (02) : 314 - 314
[36] EFFECTS OF FLAVONOIDS ON HIGH DOSE GLUCOSE PLUS TUMOR NECROSIS FACTOR-A-INDUCED THE INTERCELLULAR ADHESION MOLECULE-1 EXPRESSION IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
Liu, Kaili
ANNALS OF NUTRITION AND METABOLISM, 2009, 55 : 409 - 409
[37] Lipoteichoic acid-induced neutrophil adhesion via E-selectin to human umbilical vein endothelial cells (HUVECs)
Kawamura, N
Imanishi, N
Koike, H
Nakahara, H
Phillips, L
Morooka, S
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 217 (03) : 1208 - 1215
[38] CLONING OF THE MOUSE ENDOTHELIAL SELECTINS - EXPRESSION OF BOTH E-SELECTIN AND P-SELECTIN IS INDUCIBLE BY TUMOR-NECROSIS-FACTOR-ALPHA
WELLER, A
ISENMANN, S
VESTWEBER, D
JOURNAL OF BIOLOGICAL CHEMISTRY, 1992, 267 (21) : 15176 - 15183
[39] Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells
Nizamutdinova, Irina Tsoy
Jeong, Jae Ju
Xu, Guang Hua
Lee, Seung-Ho
Kang, Sam Sik
Kim, Yeong Shik
Chang, Ki Churl
Kim, Hye Jung
INTERNATIONAL IMMUNOPHARMACOLOGY, 2008, 8 (05) : 670 - 678
[40] CYTOKINE-INDUCED E-SELECTIN EXPRESSION BY HUMAN UMBILICAL VEIN ENDOTHELIAL-CELLS (HUVEC) - A ROLE FOR PROTEIN-TYROSINE KINASES
MAY, MJ
WHEELERJONES, CPD
PEARSON, JD
BIOCHEMICAL SOCIETY TRANSACTIONS, 1995, 23 (02) : S182 - S182

← 1 2 3 4 5 →