Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-α

被引：37
|
作者：
Takano-Ishikawa, Y [1 ]
Goto, M [1 ]
Yamaki, K [1 ]
机构：
[1] Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan
来源：
PHYTOTHERAPY RESEARCH | 2003年 / 17卷 / 10期
关键词：
flavonoids; E-selectin; tumor necrosis factor; human umbilical vein endothelial cell;
D O I：
10.1002/ptr.1371
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The present study investigates the suppressive effect of flavonoids on TNF-alpha-stimulated E-selectin expression on HUVECs by carrying out a comparative examination of the 37 flavonoids. Several flavonoids: fisetin, luteolin and apigenin (subclass of flavone), kaempferol and quercetin (flavonols), eriodictyol (flavanones), genistein (isoflavones) and butein (chalcone) exhibit the inhibitory effects. Considerations to the structure of flavonoids, the C2-C3 double bond of C-ring and 4-oxo functional group are essential for their inhibition activities. These results help to explain the pharmacological efficacy of flavonoids as anti-inflammatory compounds. Copyright (C) 2003 John Wiley Sons, Ltd.
引用
收藏
页码：1224 / 1227
页数：4
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