A new anti-proliferative acylated flavonol glycoside from Fuzhuan brick-tea

被引：39

作者：

Tian, Yong-Zhen ^{[1
]}

Liu, Xiao ^{[1
]}

Liu, Wen ^{[2
]}

Wang, Wei-Yun ^{[2
]}

Long, Yan-Hua ^{[2
]}

Zhang, Liang ^{[1
]}

Xu, Yan ^{[1
]}

Bao, Guan-Hu ^{[1
]}

Wan, Xiao-Chun ^{[1
]}

Ling, Tie-Jun ^{[1
]}

机构：

[1] Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, Hefei, Peoples R China

[2] Anhui Agr Univ, Sch Life Sci, Hefei, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 23期

关键词：

Fuzhuan brick-tea; dark tea; camellikaempferoside A; anti-proliferative activity; MCF-7; cells; MDA-MB-231; FERMENTED CAMELLIA-SINENSIS; MICROBIAL FERMENTATION; HUMAN HEALTH; CONSTITUENTS; CATECHINS; OLEIFERA;

D O I：

10.1080/14786419.2015.1136911

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Fuzhuan brick-tea (FBT) is unique for a fungal fermentation stage in its manufacture process and is classified in dark tea. A new acylated flavonol glycoside, kaempferol 3-O-[E-p-coumaroyl-(2)][-l-arabinopyranosyl-(13)][-l-rhamnopyranosyl(16)]--d-glucopyranoside, which was trivially named as camellikaempferoside A (1), was isolated from FBT along with camelliquercetiside C (2). Their structures were unambiguously elucidated by combination of spectroscopic and chemical methods. Compound 1 showed anti-proliferative activity against MCF-7 and MDA-MB-231 cells with IC50 values of 7.83 and 19.16M, respectively. [GRAPHICS] .

引用

页码：2637 / 2641

页数：5

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