A new anti-proliferative acylated flavonol glycoside from Fuzhuan brick-tea

Fuzhuan brick-tea (FBT) is unique for a fungal fermentation stage in its manufacture process and is classified in dark tea. A new acylated flavonol glycoside, kaempferol 3-O-[E-p-coumaroyl-(2)][-l-arabinopyranosyl-(13)][-l-rhamnopyranosyl(16)]--d-glucopyranoside, which was trivially named as camellikaempferoside A (1), was isolated from FBT along with camelliquercetiside C (2). Their structures were unambiguously elucidated by combination of spectroscopic and chemical methods. Compound 1 showed anti-proliferative activity against MCF-7 and MDA-MB-231 cells with IC50 values of 7.83 and 19.16M, respectively. [GRAPHICS] .