Design and Realization of Label-free Optical Immunosensor Based on Porous Silicon Microcavities

被引：0
|
作者：
Lue, Xiao-yi [1 ,3 ]
Xue, Tao [2 ]
Jia, Zhen-hong [3 ]
Shao, Hua-wei [2 ]
Hou, Shi-bin [4 ]
Zhang, Fu-chun [4 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Elect & Informat Engineer, Xian 710049, Peoples R China
[2] Xinjiang Univ, Sch Phys, Uruqi 830046, Peoples R China
[3] Xinjiang Univ, Coll Informat Sci & Engn, Uruqi 830046, Peoples R China
[4] Xinjiang Univ, Coll Life Sci & Technol, Key Lab Xinjiang Biol Resources & Gene Engn, Uruqi 830046, Peoples R China
来源：
2008 INTERNATIONAL CONFERENCE ON OPTICAL INSTRUMENTS AND TECHNOLOGY: ADVANCED SENSOR TECHNOLOGIES AND APPLICATIONS | 2009年 / 7157卷
关键词：
porous silicon; HSYA; immunosensor; microcavity; HYDROXYSAFFLOR-YELLOW-A; REFRACTIVE-INDEX; MULTILAYER; BIOSENSOR;
D O I：
10.1117/12.811386
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
We report the experimental demonstration of a novel label-free optical immunosensor based on porous silicon microcavity for the detection of Hydroxysafflor yellow A (HSYA). HSYA antibodies were immobilized into the porous silicon using standard amino-silane and glutaraldehyde chemistry. We monitor the shift of the resonance dip in the reflectance spectrum when HSYA-BSA is attached to the porous silicon microcavity. The label-free immunosensor is simple and exhibit excellent sensitivity for HSYA antibodies with a sensitivity of 0.91nm/ng.
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页数：8
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