Design and Realization of Label-free Optical Immunosensor Based on Porous Silicon Microcavities

被引：0

作者：

Lue, Xiao-yi ^{[1
,3
]}

Xue, Tao ^{[2
]}

Jia, Zhen-hong ^{[3
]}

Shao, Hua-wei ^{[2
]}

Hou, Shi-bin ^{[4
]}

Zhang, Fu-chun ^{[4
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Elect & Informat Engineer, Xian 710049, Peoples R China

[2] Xinjiang Univ, Sch Phys, Uruqi 830046, Peoples R China

[3] Xinjiang Univ, Coll Informat Sci & Engn, Uruqi 830046, Peoples R China

[4] Xinjiang Univ, Coll Life Sci & Technol, Key Lab Xinjiang Biol Resources & Gene Engn, Uruqi 830046, Peoples R China

来源：

2008 INTERNATIONAL CONFERENCE ON OPTICAL INSTRUMENTS AND TECHNOLOGY: ADVANCED SENSOR TECHNOLOGIES AND APPLICATIONS | 2009年 / 7157卷

关键词：

porous silicon; HSYA; immunosensor; microcavity; HYDROXYSAFFLOR-YELLOW-A; REFRACTIVE-INDEX; MULTILAYER; BIOSENSOR;

D O I：

10.1117/12.811386

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

We report the experimental demonstration of a novel label-free optical immunosensor based on porous silicon microcavity for the detection of Hydroxysafflor yellow A (HSYA). HSYA antibodies were immobilized into the porous silicon using standard amino-silane and glutaraldehyde chemistry. We monitor the shift of the resonance dip in the reflectance spectrum when HSYA-BSA is attached to the porous silicon microcavity. The label-free immunosensor is simple and exhibit excellent sensitivity for HSYA antibodies with a sensitivity of 0.91nm/ng.

引用

页数：8

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