Electrocatalytic C(sp3)-H/C(sp)-H cross-coupling in continuous flow through TEMPO/copper relay catalysis

被引：6
|
作者：
Guo, Bin
Xu, Hai-Chao [1 ]
机构：
[1] Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen, Peoples R China
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 17卷
关键词：
continuous flow; copper; catalysis; dehydrogenative cross-coupling; electrochemistry; C-H BONDS; ASYMMETRIC ALKYNYLATION; ELECTROCHEMISTRY; METAL; METALLAELECTROCATALYSIS; OXIDATION; ADJACENT;
D O I：
10.3762/bjoc.17.178
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Electrocatalytic dehydrogenative C(sp3)-H/C(sp)-H cross-coupling of tetrahydroisoquinolines with terminal alkynes has been achieved in a continuous-flow microreactor through 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)/copper relay catalysis. The reaction is easily scalable and requires low concentration of supporting electrolyte and no external chemical oxidants or ligands, providing straightforward and sustainable access to 2-functionalized tetrahydroisoquinolines.
引用
收藏
页码：2650 / 2656
页数：7
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